Occupational exposure to chloromethyl ethers: a retrospective cohort mortality study (1948-1972).

Details

• Personal Author:
  Albert RE ; Pasternack BS ; Shore RE
• Description:
  This industry-wide epidemiologic study to evaluate the human carcinogenicity of chloromethyl-methyl-ether (107302) containing the contaminant bis-chloromethyl-ether (542881) included 1827 exposed workers and 8870 controls. Duration and relative intensity of exposure were classified by job description in the personnel records. This information permitted assigning relative magnitude of exposure scores for each job category at several plants, with allowance for temporal changes in the plant processes. Social security records were used for the ascertainment of deaths among separated employees. Death certificates were obtained for virtually all known deaths, and hospital pathology reports were obtained where possible for the cancer related deaths. No differences in noncancer death rates were found. An increased risk of respiratory cancer death in exposed workers was found at only one firm where high exposures are known to have occurred. A clear dose-response relationship with risk ratios exceeding ten for the longest duration and greatest exposure subgroups was demonstrated for this firm. (Contract No. 210-75-0062) [Description provided by NIOSH]
• Subjects:
  Carcinogens Ether Lung Lung Diseases Manufacturing And Industrial Facilities Mortality Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Chemical-industry-workers Chemical-manufacturing-industry Contract-210-75-0062 Dose-response Ethers Halogenated-compounds Hazards JOCMA7 Lung-cancer NIOSH-Contract NIOSH-Publication Respiratory-system-disorders

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• ISSN:
  0096-1736
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  11
• NIOSHTIC Number:
  nn:00074833
• Citation:
  J Occup Med 1977 Nov; 19(11):741-746
• CAS Registry Number:
  Chloromethyl ether (CAS RN 542-88-1) ; Chloromethyl methyl ether (CAS RN 107-30-2)
• Federal Fiscal Year:
  1978
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3f6007807e6cb4507e2419926e667104ac2b9a4a7a3812e3636af31bff2a075ea02bf9f5cce8e475f916bc84562a90681ea953856a6742a87c4d5e2e4717f1d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/184216/cdc_184216_DS1.pdf
• File Type:
  [PDF - 706.85 KB ]