Chloro ethers -- occupational carcinogens, a summary of laboratory and epidemiology studies.

Details

• Personal Author:
  Nelson N
• Description:
  The relationship between chemical structure and carcinogenicity of a group of chloroethers is briefly reviewed, with data summarized from an extensive series of studies at the New York University Institute of Environmental Medicine on the chloroethers. Bis(chloromethyl)ether (542881) (BCME) and its monofunctional analog, chloromethyl-methyl-ether (107302) (CMME) produce tumors in subcutaneous tissue and skin in rodents. BCME is a highly potent vapor carcinogen for the rat lung and for the epithelial sheathing of the nasal nerve. Hydrochloric-acid (7647010) and formaldehyde (50000) can combine to form BCME. The extent of hazard from this combination is unknown. Epidemiologic studies of workers involved in chloroether manufacture have led to the identification of 34 cases of lung cancer in the United States and 13 in Europe. Active but less potent chloroethers have been identified in municipal drinking water in the United States. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Carcinogens Epidemiology Ether Halothane Hazardous Substances Irritants Lung Lung Diseases Manufacturing And Industrial Facilities Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Skin Skin Diseases

  More +
• Keywords:
  NIOSH-Contract; Contract-210-75-0062; Ethers; Halogenated-hydrocarbons; Carcinogens; Toxic-substances; Carcinogenesis; Respiratory-irritants; Respiratory-system-disorders; Skin-neoplasms; Epidemiology; Chemical-manufacturing-industry; Chemical-industry-workers; Lung-neoplasms
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-22
• NIOSHTIC Number:
  nn:00080684
• NTIS Accession Number:
  PB83115352
• Citation:
  NIOSH 1975 Jun; :1-22
• CAS Registry Number:
  Chloromethyl ether (CAS RN 542-88-1) ; Chloromethyl methyl ether (CAS RN 107-30-2) ; Formaldehyde (CAS RN 50-00-0) ; Hydrochloric acid (CAS RN 7647-01-0)
• Federal Fiscal Year:
  1975
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH, Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/240797/cdc_240797_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]