Dose-Response Assessment Issues in Occupational Mortality Studies

Details

• Personal Author:
  Arrighi HM ; Hertz-Picciotto I ; Lee JT
• Description:
  This project examined absenteeism as a surrogate for ill health and its usefulness in the context of the differential survival problem. The data came from an occupational cohort study of arsenic (7440382) and lung cancer. The cohort consisted of all white male workers employed for 1 year or more between 1940 and 1964 at a copper smelter in Tacoma, Washington. After controlling for the level of current exposure, age at hire and year at hire, the risk of having a 30 day or longer absence was generally higher with increased level of cumulative exposure. In contrast, current exposure level shows an inverse relationship with absence. The mortality analysis suggests that a recent absence of more than 30 days was associated with a higher risk of death from respiratory cancer among employees exposed to arsenic. The authors caution that information on absenteeism without knowledge of the reasons for the absence is not in and of itself useful in such studies. [Description provided by NIOSH]
• Subjects:
  Carcinogens Epidemiology Lung Lung Diseases Mortality Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Cancer-rates Grants-other Lung-cancer Mortality-surveys NIOSH-Grant Respiratory-system-disorders Worker-health
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  North Carolina ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-24
• NIOSHTIC Number:
  nn:00228284
• NTIS Accession Number:
  PB95-269908
• Citation:
  Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 1995 Feb; :1-24
• Contact Point Address:
  Epidemiology Univ of North Carolina Cb#7400 Mcgavran Greenberg HAl Chapel Hill, NC 27599-7400
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  1995
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of North Carolina Chapel Hill, Chapel Hill, North Carolina
• Peer Reviewed:
  False
• Start Date:
  19920301
• Source Full Name:
  Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
• End Date:
  19940929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b8e95dc10994e608aaeb7c4495b9dc926d9a039920248467f54a6df3ecc9f1b8cfb4cf61f919fe7bad262808fccd94cfe87a07a6e1bbba7a382064533d3ce9c7
• Download URL:
  https://stacks.cdc.gov/view/cdc/217851/cdc_217851_DS1.pdf
• File Type:
  [PDF - 620.55 KB ]