Studies of zinc metabolism in the rat I. Dose-response effects of cadmium.

Details

• Personal Author:
  Johnson MA ; Petering HG ; Stemmer KL
• Description:
  Experiments were designed to determine the effects of cadmium (7440439) on zinc (7440666) metabolism in male rats. Zinc is necessary for growth; a one to one ratio of zinc to cadmium in the drinking water inhibits growth, but when the ratio is four to one growth is not affected. Skin disorders were observed in zinc deficient rats with or without cadmium. Body temperature control and copper (7440508) distribution were affected by zinc uptake. Cadmium altered the responses inversely in relation to zinc intake, and can be considered an antimetabolite of zinc, cadmium was localized in the liver and kidneys but not in the testes. There is very little storage of readily available zinc in the male rat. [Description provided by NIOSH]
• Subjects:
  Metals Metals, Heavy Occupational Health Safety Somatotypes
• Keywords:
  Antimetabolites Body-distribution Heavy-metals NIOSH-Grant NIOSH-Publication Physiological-response Transition-metals
• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  93-101
• Volume:
  23
• Issue:
  2
• NIOSHTIC Number:
  nn:00069303
• Citation:
  Arch Environ Health 1971 Aug; 23(2):93-101
• Contact Point Address:
  Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Copper (CAS RN 7440-50-8) ; Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  1971
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Archives of Environmental Health
• End Date:
  19790831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:de735ac6bce36585ca7f0767be52a681db3b6f30a24f91f0ad02e15742309459bd62e70d7c4a6e5b45aeb978633c420c49578067e5d91319569f55ecbf721702
• Download URL:
  https://stacks.cdc.gov/view/cdc/184142/cdc_184142_DS1.pdf
• File Type:
  [PDF - 2.18 MB ]