Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  MacDougall, Laura ; Fyfe, Murray ; Romney, Marc ; Starr, Mike ; Galanis, Eleni
• Description:
  To determine whether particular environmental, medical, or behavioral risk factors existed among Cryptcoccus gattii-infected persons compared with the general population, we conducted a sex-matched case-control study on a subset of case-patients in British Columbia (1999-2001). Exposures and underlying medical conditions among all case-patients (1999-2007) were also compared with results of provincial population-based surveys and studies. In case-control analyses, oral steroids (matched odds ratio [MOR] 8.11, 95% confidence interval [CI] 1.74-37.80), pneumonia (MOR 2.71, 95% CI 1.05-6.98), and other lung conditions (MOR 3.21, 95% CI 1.08-9.52) were associated with infection. In population comparisons, case-patients were more likely to be ≥50 years of age (p<0.001), current smokers (p<0.001), infected with HIV (p<0.001), or have a history of invasive cancer (p<0.001). Although C. gattii is commonly believed to infect persons with apparently healthy immune systems, several immunosuppressive and pulmonary conditions seem to be risk factors.
• Subjects:
  Aged Aged, 80 And Over Case-Control Studies Cryptococcosis Female Humans Immunocompromised Host Interviews As Topic Male Middle Aged Neoplasms Questionnaires Risk Factors Smoking

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• Source:
  Emerg Infect Dis. 17(2):193-199.
• Document Type:
  Journal Article
• Place as Subject:
  British Columbia, Canada
• Volume:
  17
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b1befafa471489ff22c0b55830d32a6c089e8ca1d0d3787f73b438f9a8bd5194
• Download URL:
  https://stacks.cdc.gov/view/cdc/18414/cdc_18414_DS1.pdf
• File Type:
  [PDF - 138.73 KB ]