Asbestos Dust: A Study on the Pathogenetic Mechanism

Details

• Personal Author:
  Gross P ; Harley RA Jr.
• Description:
  Samples of crocidolite (12001284), amosite (12172735), and Canadian chrysotile (12001295) were prepared by five different methods for intratracheal injection to rats. A fairly high mortality was noted in the first 6 months, generally from pneumonia. Of the 1537 rats injected intratracheally one to four times, only 727 rats survived 6 months. The total dosage ranged from 1.75 to 21 milligrams. The results of the study indicated that the intratracheal injection of the three most important asbestos (1332214) dusts into rats caused no induction of cancer. It made no difference to the outcome whether these dusts were natural or had been modified by the addition or subtraction of trace metals, or whether the dusts had been heated. A significant lessening of the fibrogenicity of asbestos dust was caused by heating the dusts. These findings suggested that the theory that trace metals assist in the pathogenic potential of asbestos dust must be abandoned. The failure of lung cancers to develop in this study as they had in previous studies could not be explained. The authors conclude that the pathogenicity of chrysotile asbestos may not be attributable to its fibrous shaped particles, its magnesium-silicate molecule, or to its crystalline character. [Description provided by NIOSH]
• Subjects:
  Asbestos Carcinogens Dust Laboratories Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Asbestos-dust Laboratory-animals Lung-cancer Mineral-dusts NIOSH-Grant Pulmonary-system-disorders
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-20
• NIOSHTIC Number:
  nn:00190682
• NTIS Accession Number:
  PB90-129396
• Citation:
  Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania 1972 Dec; :1-20
• Contact Point Address:
  None Industrial Hlth Fdn, Inc 5231 Centre Avenue Pittsburgh, PA 15232
• CAS Registry Number:
  Amosite asbestos (CAS RN 12172-73-5) ; Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5) ; Crocidolite asbestos (CAS RN 12001-28-4)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Industrial Health Foundation, Pittsburgh, Pennsylvania
• Peer Reviewed:
  False
• Start Date:
  19710601
• Source Full Name:
  Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania
• End Date:
  19760531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:267389a9a96558183fd77fdae42aedda06c368edb50cc0297a052699872366f6ef32e999d44e39413fe0ea6dae6ae8373d2f2b8e4773c19a8648abea71471886
• Download URL:
  https://stacks.cdc.gov/view/cdc/217766/cdc_217766_DS1.pdf
• File Type:
  [PDF - 645.25 KB ]