Paint-remover hazard.

Details

• Personal Author:
  Hake CL ; Stewart RD
• Description:
  The in home use of paint removers containing methylene-chloride (75092) results in the absorption of this solvent, which is metabolized to carbon-monoxide (630080). Exposure for two to three hours can result in the elevation of carboxyhemoglobin to levels that stress the cardiovascular system. The metabolic formation of carboxyhemoglobin continues following the paint remover exposure, doubling the duration of the cardiovascular stress produced by a comparable carboxyhemoglobin level after exposure to carbon- monoxide. Patients with diseased cardiovascular systems may not be able to tolerate this unexpected stress. One case history illustrates the tragedy that can occur when a patient with coronary heart disease is exposed to a paint and varnish remover containing methylene-chloride and the solvent is metabolized to a toxic amount of carbon-monoxide. The second case described in detail is the one in which the in-vivo metabolism of methylene-chloride to carbon- monoxide was first observed. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Chlorine Compounds Energy Metabolism Hematologic Diseases Hydrocarbons Occupational Health Safety Solvents Toxicology
• Keywords:
  Blood-disorders Cardiovascular-system-disorders Chlorinated-hydrocarbons Chlorinated-methanes Contract-099-72-0084 Metabolites NIOSH-Contract NIOSH-Publication Organic-solvents
• ISSN:
  0098-7484
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  398-401
• Volume:
  235
• Issue:
  4
• NIOSHTIC Number:
  nn:00059540
• Citation:
  JAMA 1976 Jan; 235(4):398-401
• Contact Point Address:
  Dr Stewart, The Medical College of Wisconsin, Allen-Bradley Medical Science Laboratory, 8700 W Wisconsin Ave, Milwaukee, WI 53226
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0) ; Dichloromethane (CAS RN 75-09-2)
• Federal Fiscal Year:
  1976
• Performing Organization:
  The Medical College of Wisconsin, Department of Environmental Medicine
• Peer Reviewed:
  True
• Source Full Name:
  Journal of the American Medical Association
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1543766cea055f7f14a54add2285c3d1cd0cd43bf3442c805eac9ca80033cb80b5ece2f8bcd52ec13458d036bd2ee6504cd16604171c1d04e06b4b25d0dee70e
• Download URL:
  https://stacks.cdc.gov/view/cdc/184130/cdc_184130_DS1.pdf
• File Type:
  [PDF - 7.34 MB ]