In vivo conversion of methylene chloride to carbon monoxide.

Details

• Personal Author:
  Elkins HB ; Ratney RS ; Wegman, David H.
• Description:
  A group of workers exposed to 180 to 200 ppm of methylene chloride had carboxyhemoglobin levels of about 4.5% as measured by alveolar carbon monoxide concentrations at the beginning of their workday. This rose to about 9% after eight hours of exposure and then dropped exponentially to 4.5% by the time they started working the next day. The 24-hour time-weighted average concentration of carboxyhemoglobin was 7.3% compared with 2.7% for persons exposed to 35 parts per million of carbon monoxide or 3.8% for persons exposed to 50 parts per million of carbon monoxide. On the basis of these observations, it is proposed that the threshold limit value for methylene chloride be reduced to 75 to 100 parts per million to avoid body burdens of carboxyhemoglobin greater than these allowed persons exposed to exogenous carbon monoxide. [Description provided by NIOSH]
• Subjects:
  Blood Chlorine Compounds Energy Metabolism Hematologic Diseases Hematologic Tests Hydrocarbons Occupational Health Respiratory System Safety Solvents Toxicology

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• Keywords:
  Blood-chemistry Blood-disorders Chlorinated-hydrocarbons Chlorinated-methanes Control-measures Exposure-limits Metabolism NIOSH-Grant NIOSH-Publication Organic-solvents Plastic-industry Prevention Respiratory-gas-analysis

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• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  223-226
• Volume:
  28
• Issue:
  4
• NIOSHTIC Number:
  nn:00046813
• Citation:
  Arch Environ Health 1974 Apr; 28(4):223-226
• Contact Point Address:
  Labor and Industries 39 Boylston Street Boston, Mass 02116
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0)
• Federal Fiscal Year:
  1974
• Performing Organization:
  Massachusetts Dept of Labor & Industries, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Archives of Environmental Health
• End Date:
  19740831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:32b28470f31320bac682021db5e3c2d0c7e98c0fc7ac93ceece7adb6b6761cdd16ba6dfd5ee71a66dcb8bb8fc89a660afc7143cd290e8823954acc408dee3678
• Download URL:
  https://stacks.cdc.gov/view/cdc/184030/cdc_184030_DS1.pdf
• File Type:
  [PDF - 503.72 KB ]