Care Hospital, Sabah, Malaysia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  William, Timothy ; Menon, Jayaram ; Rajahram, Giri ; Chan, Leslie ; Ma, Gordon ; Donaldson, Samantha ; Khoo, Serena ; Fredrick, Charlie ; Jelip, Jenarun ; Anstey, Nicholas M. ; Yeo, Tsin Wen
• Description:
  The simian parasite Plasmodium knowlesi causes severe human malaria; the optimal treatment remains unknown. We describe the clinical features, disease spectrum, and response to antimalarial chemotherapy, including artemether-lumefantrine and artesunate, in patients with P. knowlesi malaria diagnosed by PCR during December 2007-November 2009 at a tertiary care hospital in Sabah, Malaysia. Fifty-six patients had PCR-confirmed P. knowlesi monoinfection and clinical records available for review. Twenty-two (39%) had severe malaria; of these, 6 (27%) died. Thirteen (59%) had respiratory distress; 12 (55%), acute renal failure; and 12, shock. None experienced coma. Patients with uncomplicated disease received chloroquine, quinine, or artemether-lumefantrine, and those with severe disease received intravenous quinine or artesunate. Parasite clearance times were 1-2 days shorter with either artemether-lumefantrine or artesunate treatment. P. knowlesi is a major cause of severe and fatal malaria in Sabah. Artemisinin derivatives rapidly clear parasitemia and are efficacious in treating uncomplicated and severe knowlesi malaria.
• Subjects:
  Acute Kidney Injury Adult Antimalarials Artemisinin Derivatives Artemisinins Artesunate Chloroquine Ethanolamines Female Fluorenes Hospitals, Urban Humans Malaria Malaysia Malaysian Borneo Microscopy Middle Aged Parasitemia Parasites Patient Selection Plasmodium Knowlesi Polymerase Chain Reaction Quinine Research Respiratory Distress Syndrome, Adult Sabab Severe Malaria Severity Of Illness Index Shock Survival Rate

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• Source:
  Emerg Infect Dis. 17(7):1248-1255.
• Document Type:
  Journal Article
• Volume:
  17
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ce5d322ad3bb876306d9be5c126ac9ce077651a7ede596604c7c71f190c1340a
• Download URL:
  https://stacks.cdc.gov/view/cdc/18413/cdc_18413_DS1.pdf
• File Type:
  [PDF - 288.33 KB ]