The effect of lung reactive antibodies on the pathogenesis of tuberculosis.

Details

• Personal Author:
  Burrell R ; Cate CC
• Description:
  Injections of washed mouse lung-CCT suspended in Freund's complete adjuvant are given to mice and guinea-pigs to stimulate production of homologous and heterologous mouse lung-reactive antibodies harvested as peritoneal ascitic fluid and serum, respectively. Reactivity of the homologous antibody is limited to relatively weak, but lung-specific, focal localization in the alveolar septa of recipient mice as demonstrated by immunofluorescence studies. An index of tuberculous involvement is developed that correlates the enhanced spread of tubercle bacilli with administration of heterologous immune serum and allowed quantitation of the immune response as a function of histopathology. The effect of heterologous immune serum on experimental tuberculosis infection is an alteration in the appearance of and an increase in the number of lesions resembling a miliary spread of the organisms not seen in the controls. [Description provided by NIOSH]
• Subjects:
  Antigens Communicable Diseases Lung Diseases Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Infectious-diseases Lung-disorders NIOSH-Grant NIOSH-Publication Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  0009-9104
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• Issue:
  6
• NIOSHTIC Number:
  nn:00038653
• Citation:
  Clin Exp Immunol 1971 Dec; 9(6):809-819
• Contact Point Address:
  Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
• Federal Fiscal Year:
  1972
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Clinical and Experimental Immunology
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:abc792bd27d8bc972c8f0f3c2d9a4899ffce600a84402bbe1bf5cd8a613eb57f3a700fe6549823fb720e16422dbcd5e4bb97d25489b04087a6b8d1aad5c6b4c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/183995/cdc_183995_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]