Adenosine 3',5'-cyclic monophosphate phosphodiesterase in guinea-pig lung-properties and effect of adrenergic drugs.

Details

• Personal Author:
  Hitchcock M
• Description:
  The hydrolysis of adenosine-3',5'-cyclic-monophosphate (60924) (cAMP) by adenosine-3',5'-monophosphate-phosphodiesterase (PDE) was studied in whole homogenates and cell fractions of guinea-pig lung. cAMP has been implicated as a controlling agent in a number of processes which govern lung function. Increases in cAMP have been associated with tracheal smooth muscle relaxation and decreases with the immunological release of histamine (51456) from human lung. The physiological responses of these systems and the intracellular cAMP levels respond to stimulation with isoproterenol, epinephrine, norepinephrine (51412), and methoxamine (390283) via both alpha and beta receptors. This report describes the results of experiments which demonstrated that guinea-pig lung contains two forms of phosphodiesterase with different affinities for cAMP and that predominately the low affinity form is affected by adrenergic drugs. [Description provided by NIOSH]
• Subjects:
  Biochemistry Cytology Endocrine System Enzymes Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Catecholamines Endocrinology Enzyme-activity Histamine NIOSH-Grant NIOSH-Publication Pharmacology Pulmonary-system Pulmonary-system-disorders Sympathetic-nervous-system Sympathomimetics

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• ISSN:
  0006-2952
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  8
• NIOSHTIC Number:
  nn:00023855
• Citation:
  Biochem Pharmacol 1973; 22(8):959-969
• Contact Point Address:
  John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
• CAS Registry Number:
  cAMP (CAS RN 60-92-4) ; Histamine (CAS RN 51-45-6) ; Methoxamine (CAS RN 390-28-3) ; Noradrenaline (CAS RN 51-41-2)
• Federal Fiscal Year:
  1973
• Performing Organization:
  John B Pierce Fdn of Conn Inc, New Haven, Connecticut
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Biochemical Pharmacology
• End Date:
  19770630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eaf32755218299fc2e2359d4ff9b1763aa206049821bb910d3255d5177c5ca48c3a061ab139ab7c1a93eba1cc081c4c61b978251ca2ceea364c34468e932a96e
• Download URL:
  https://stacks.cdc.gov/view/cdc/183871/cdc_183871_DS1.pdf
• File Type:
  [PDF - 766.72 KB ]