Implantation of exogenous enzymatic activity in isolated alveolar macrophages.

Details

• Personal Author:
  Acevedo JC ; Robin ED ; Theodore J
• Description:
  Alveolar macrophages are found to acquire the capacity to oxidize uric-acid (69932) after exposure to uricase. This is presumed to have resulted from intracellular incorporation of the exogenous enzyme by endocytosis. This approach may provide a general method for; testing regulatory biochemical mechanism; therapeutic replacement of deficient regulatory macromolecules; and studying environmental factors that produce genetic alterations. [Description provided by NIOSH]
• Subjects:
  Cytology Enzymes Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Enzyme-activity Mutation NIOSH-Grant NIOSH-Publication Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  0036-8075
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  178
• Issue:
  4067
• NIOSHTIC Number:
  nn:00038657
• Citation:
  Science 1972 Dec; 178(4067):1302-1304
• Contact Point Address:
  Physiology Stanford University Sch of Med Department of Medicine Palo Alto, Calif
• CAS Registry Number:
  Uric acid (CAS RN 69-93-2)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Stanford University, Stanford, California
• Peer Reviewed:
  True
• Start Date:
  19710501
• Source Full Name:
  Science
• End Date:
  19790430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:16493635ca9171d1ef1f4987a040a588d06b94ea350f36d9ae27c1ff326de8ac186afa92025164bc79f407e93d57f3ac5b5fad003538e72d1de3629fad2a7f70
• Download URL:
  https://stacks.cdc.gov/view/cdc/183998/cdc_183998_DS1.pdf
• File Type:
  [PDF - 696.51 KB ]