Histamine release from human lung by a component of cotton bracts.

Details

• Personal Author:
  Bouhuys A ; Hitchcock M ; Piscitelli DM
• Description:
  Studies to determine the localization of the histamine-releasing agent in the cotton plant revealed that only the bracts extract contained significant activity. No histamine could be detected following incubation of lung tissue with extracts of pericarps or fibers. Detectable amounts of histamine were released by the bracts extract in eight of 17 trials. The individual variation in the amount of histamine released by compound 48/80 was also wide and varied from 11.9% to 55.4% of the total histamine present. A steam volatile component of bract extract responsible for the release of histamine was found to have the same properties as methyl piperonylate. Histamine release by methyl piperonylate was stimulated by propranolol hydrochloride and inhibited by isoproterenol hydrochloride and theophylline thus implicating adenosine monophosphate in the releasing process. [Description provided by NIOSH]
• Subjects:
  Biochemistry Cytology Dust Enzymes Hypersensitivity Occupational Health Respiratory System Safety
• Keywords:
  Biochemical-processes Cotton-dust Drugs Enzyme-activity Histamine-liberation NIOSH-Grant NIOSH-Publication Pharmacology Respiratory-system Sensitization
• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  177-182
• Volume:
  26
• Issue:
  4
• NIOSHTIC Number:
  nn:00023854
• Citation:
  Arch Environ Health 1973 Apr; 26(4):177-182
• Contact Point Address:
  John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
• CAS Registry Number:
  (±)-Isoproterenol hydrochloride (CAS RN 51-30-9) ; Adenosine monophosphate (CAS RN 61-19-8) ; Histamine (CAS RN 51-45-6) ; Propranolol hydrochloride (CAS RN 318-98-9) ; Theophylline (CAS RN 58-55-9)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  John B Pierce Fdn of Conn Inc, New Haven, Connecticut
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Archives of Environmental Health
• End Date:
  19770630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:322a81556a8006138464bc35a7ad7e2fd8ef0ab98cfc58a9d1d6a034e38e9483cb43cf90edb6fb3310b7a1cff241528da2b0322fad0d29a2e595ba1eaf6a920f
• Download URL:
  https://stacks.cdc.gov/view/cdc/183870/cdc_183870_DS1.pdf
• File Type:
  [PDF - 4.69 MB ]