Sensory irritation of the upper airways by airborne chemicals.

Details

• Personal Author:
  Alarie Y
• Description:
  Tests are conducted on 27 chemicals, all containing a double carbon group, to determine their potential sensory irritation properties to the upper respiratory tract when administered in aerosol form to mice. The essential molecular features for sensory irritant activity in these compounds are delineated. Correlation between the biological and chemical reactivity data suggests that these compounds initiate the sensory irritation reaction by associating with SH groups of a receptor molecule on the free nerve endings of the afferent trigeminal which are located at the surface of the nasal mucosa. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Biochemistry Irritants Occupational Health Particulate Matter Respiratory Tract Diseases Safety Sense Organs Sulfhydryl Compounds
• Keywords:
  Air-contamination Airborne-particles NIOSH-Grant NIOSH-Publication Pulmonary-system-disorders Respiratory-irritants Sensory-perceptual-processes Sulfhydryls Thiols
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  279-297
• Volume:
  24
• Issue:
  2
• NIOSHTIC Number:
  nn:00023581
• Citation:
  Toxicol Appl Pharmacol 1973 Feb; 24(2):279-297
• Contact Point Address:
  Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19711001
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19860531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4261621452d4b37c89d73730db4332e5ec1343ecf20ddb3d36abe971cb6795d8ebfc3e960ffa427f45b8f6943b72a417bdcc396522e91f2e218ecb59143414be
• Download URL:
  https://stacks.cdc.gov/view/cdc/183858/cdc_183858_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]