Acute effects of ozone on lungs of cats. I. Functional.

Details

• Personal Author:
  Frank R ; Watanbe S ; Yokoyama E
• Description:
  Changes in respiratory mechanics and single-breath diffusing capacity for carbon monoxide are compared in cats during exposure to low concentrations of ozone. Data are given for mean time after onset of exposure to ozone before maximal increase in pulmonary resistance occurs; mean effect of atropine on pulmonary flow resistance; mean changes in dynamic compliance during ambient air breathing, exposure to ozone, and after atropine; and estimated ambient concentrations of ozone that would allow the gas to reach the upper trachea in intact animals. Results indicate that acute exposure to low concentrations of ozone affects the caliber of the airways more than either the transfer of carbon monoxide across the alveolar-capillary membrane or alveolar surface forces (in the absence of pulmonary edema). The structural changes in the lungs are found to be consistent with the functional changes. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Irritants Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Histopathology Morphology NIOSH-Grant NIOSH-Publication Pharmacology Physiological-responses Pulmonary-functions Respiratory-disorders Toxic-gases
• ISSN:
  0003-0805
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  108
• Issue:
  5
• NIOSHTIC Number:
  nn:00023061
• Citation:
  Am Rev Respir Dis 1973 Nov; 108(5):1141-1151
• Contact Point Address:
  Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
• CAS Registry Number:
  (±)-Atropine (CAS RN 51-55-8) ; Carbon monoxide (CAS RN 630-08-0) ; Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  1974
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19701001
• Source Full Name:
  American Review of Respiratory Disease
• End Date:
  19770331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c553ece0ffbee6358abf64d4359a053bde7da68e9dc6266a683341f63d5d7e30506184962f1ce4fa83de5d91913f085b17617a521bf05ea3733abcb8c803c178
• Download URL:
  https://stacks.cdc.gov/view/cdc/183848/cdc_183848_DS1.pdf
• File Type:
  [PDF - 742.60 KB ]