Morphologic and ultrastructural changes in the lungs of animals during acute exposure to ozone.

Details

• Personal Author:
  Boatman ES ; Frank R
• Description:
  Light microscopy, scanning electron microscopy, and transmission electron microscopy studies are made of the morphologic and ultrastructural changes occurring in the respiratory system of cats and rabbits exposed to low concentrations of ozone. Considerable desquamation is produced by ozone in airway lining cells, the degree of damage being proportional to the concentration (0.25, 0.5, and 1.0 ppm for 3 to 4.5 hours). Ciliated cells sustain more damage than goblet cells, mucus secreting cells or cuboidal cells, and many ciliated cells are found free in the airway luminae, desquamation frequently exposing the underlying basal cells and the basement membrane of the lamina propria. [Description provided by NIOSH]
• Subjects:
  Cytology Diagnosis Hazardous Substances Irritants Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Acute-intoxication Cytopathology Diagnostic-methods Histopathology Mitochondria NIOSH-Grant NIOSH-Publication Respiratory-system-disorders Toxic-gases
• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  9-11
• Volume:
  65
• Issue:
  4
• NIOSHTIC Number:
  nn:00028102
• Citation:
  Chest 1974 Apr; 65(4):9-11
• Contact Point Address:
  Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  1974
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19701001
• Source Full Name:
  Chest
• End Date:
  19770331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d38fde805c11b287cb452c94a5996cb486b873b1df73b3bfe1c01be28750d7be2aa19576ffbdcdc0876e0c53606b96328c1b5efb97e14f41887af8ca0e136662
• Download URL:
  https://stacks.cdc.gov/view/cdc/183923/cdc_183923_DS1.pdf
• File Type:
  [PDF - 795.88 KB ]