Determinants of Multidrug-Resistant Tuberculosis Clusters, California, USA, 2004–2007

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Metcalfe, John Z. ; Kim, Elizabeth Y. ; Lin, S.-Y. Grace ; Cattamanchi, Adithya ; Oh, Peter ; Flood, Jennifer ; Hopewell, Philip C. ; Kato-Maeda, Midori
• Description:
  Laboratory and epidemiologic evidence suggests that pathogen-specific factors may affect multidrug-resistant (MDR) tuberculosis (TB) transmission and pathogenesis. To identify demographic and clinical characteristics of MDR TB case clustering and to estimate the effect of specific isoniazid resistance-conferring mutations and strain lineage on genotypic clustering, we conducted a population-based cohort study of all MDR TB cases reported in California from January 1, 2004, through December 31, 2007. Of 8,899 incident culture-positive cases for which drug susceptibility information was available, 141 (2%) were MDR. Of 123 (87%) strains with genotype data, 25 (20%) were aggregated in 8 clusters; 113 (92%) of all MDR TB cases and 21 (84%) of clustered MDR TB cases occurred among foreign-born patients. In multivariate analysis, the katG S315T mutation (odds ratio 11.2, 95% confidence interval 2.2-Yen; p = 0.004), but not strain lineage, was independently associated with case clustering.
• Subjects:
  Adolescent Adult Antitubercular Agents Bacterial Proteins Catalase Cluster Analysis Drug Resistance, Multiple, Bacterial Female Genes, Bacterial Genotype Humans Isoniazid Male Middle Aged Molecular Epidemiology Multivariate Analysis Point Mutation Research Rifampin Tuberculosis, Multidrug-Resistant Young Adult

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• Source:
  Emerg Infect Dis. 16(9):1403-1409.
• Document Type:
  Journal Article
• Place as Subject:
  California
• Location:
  North America
• Volume:
  16
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cdf1d55b08113ebe42f8bc930b322ef7b866c965f0b6d4c2fcf197387a366c1e
• Download URL:
  https://stacks.cdc.gov/view/cdc/18257/cdc_18257_DS1.pdf
• File Type:
  [PDF - 214.70 KB ]