Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis

Details

• Alternative Title:
  Int J Tuberc Lung Dis
• Personal Author:
  Feng, J-Y. ; Jarlsberg, L. G. ; Salcedo, K. ; Rose, J. ; Janes, M. ; Lin, S-Y. G. ; Osmond, D. H. ; Jost, K. C. ; Soehnlen, M. K. ; Flood, J. ; Graviss, E. A. ; Desmond, E. ; Moonan, P. K. ; Nahid, P. ; Hopewell, P. C. ; Kato-Maeda, M.
• Description:
  SETTING
  
  The impact of the genetic characteristics of Mycobacterium tuberculosis on the clustering of multi-drug-resistant tuberculosis (MDR-TB) has not been analyzed together with clinical and demographic characteristics.
  
  OBJECTIVE
  
  To determine factors associated with genotypic clustering of MDR-TB in a community-based study.
  
  DESIGN
  
  We measured the proportion of clustered cases among MDR-TB patients and determined the impact of clinical and demographic characteristics and that of three M. tuberculosis genetic characteristics: lineage, drug resistance-associated mutations, and rpoA and rpoC compensatory mutations.
  
  RESULTS
  
  Of 174 patients from California and Texas included in the study, the number infected by East-Asian, Euro-American, Indo-Oceanic and East-African-Indian M. tuberculosis lineages were respectively 70 (40.2%), 69 (39.7%), 33 (19.0%) and 2 (1.1%). The most common mutations associated with isoniazid and rifampin resistance were respectively katG S315T and rpoB S531L. Potential compensatory mutations in rpoA and rpoC were found in 35 isolates (20.1%). Hispanic ethnicity (OR 26.50, 95%CI 3.73–386.80), infection with an East-Asian M. tuberculosis lineage (OR 30.00, 95%CI 4.20–462.40) and rpoB mutation S531L (OR 4.03, 95%CI 1.05–23.10) were independent factors associated with genotypic clustering.
  
  CONCLUSION
  
  Among the bacterial factors studied, East-Asian lineage and rpoB S531L mutation were independently associated with genotypic clustering, suggesting that bacterial factors have an impact on the ability of M. tuberculosis to cause secondary cases.
  
  
• Subjects:
  Adult Antitubercular Agents Bacterial Proteins Cluster Analysis Drug Resistance, Multiple, Bacterial Female Genotype Humans Isoniazid Male Microbial Sensitivity Tests Middle Aged Mutation Mycobacterium Tuberculosis Rifampin Tuberculosis, Multidrug-Resistant Young Adult

  More +
• Keywords:
  Community-based Study Molecular Epidemiology Transmission
• Source:
  Int J Tuberc Lung Dis. 21(7):766-773
• Pubmed ID:
  28513421
• Pubmed Central ID:
  PMC6643968
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/ ; R01 AI076476/AI/NIAID NIH HHSUnited States/ ; R01 AI104589/AI/NIAID NIH HHSUnited States/
• Place as Subject:
  California ; Texas
• Volume:
  21
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:470cce10a98cef7881f0d1157b6694188ca22fd3bc1f0bde49fccfd4cbfffe51
• Download URL:
  https://stacks.cdc.gov/view/cdc/80056/cdc_80056_DS1.pdf
• File Type:
  [PDF - 363.20 KB ]