A dose-response analysis and quantitative assessment of lung cancer risk and occupational cadmium exposure.

Details

• Personal Author:
  Lemen R ; Schnorr T ; Smith R ; Stayner L ; Thun M
• Description:
  A quantitative assessment was performed of the risk of lung cancer from exposure to cadmium (7440439) in a population of workers at a facility that processed cadmium metals and compounds. The population consisted of all workers who worked in a production area for at least 6 months from 1940 through 1969; the vital status of the workers was updated through 1984. A total of 606 white male workers, contributing 16,898 person years and 162 deaths were analyzed. A statistically significant dose response was evident in nearly all of the Poisson regression models evaluated. A nearly significant excess in mortality from lung cancer was noted for the entire cohort. Mortality from lung cancer was significantly elevated among nonHispanic workers, workers in the highest cadmium exposure group, and among workers with 20 or more years since first exposure. Based on these analyses, the lifetime excess lung cancer risk at the current OSHA standard for cadmium fumes of 100 micrograms per cubic meter was estimated to be approximately 50 to 111 lung cancer deaths per 1000 workers exposed to cadmium for 45 years. The authors conclude that efforts should be made to further reduce the risk by lowering occupational exposures to cadmium to the lowest level feasible.
• Subjects:
  Accidents, Occupational Nervous System Nervous System Diseases Occupational Health Risk Assessment Safety
• Keywords:
  Cadmium-compounds Cancer-rates Carcinogens Epidemiology Lung-cancer NIOSH-Author Occupational-exposure Respiratory-system-disorders Risk-analysis
• Document Type:
  Text
• Genre:
  Other
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-35
• NIOSHTIC Number:
  nn:00206158
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, 1990 Sep; :1-35
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:148bde73f1a3576da9c7fd823f68c6d861d901c4345eec891a582fd09baeaf9415d72215b44787e3edfaa44da8ff86ab1420c1e95590a038570436ee31906356
• Download URL:
  https://stacks.cdc.gov/view/cdc/180756/cdc_180756_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]