Autoimmunity phenomena and alterations of humoral immunological responses in silicotic patients.

Details

• Personal Author:
  Idel H ; Prugger F ; Seemayer NH
• Description:
  Four groups of silicotic patients were examined including 34 miners who had radiologically manifest fibrosis following exposure for 15 years, 40 miners who demonstrated no radiological signs of silicosis even after exposure for more than 30 years, 48 stone masons and quarriers, and a referent group of 25 nonexposed men. Lysozyme, angiotensin converting enzyme, and fibronectin revealed significantly higher values in coal mine workers with and without pneumoconiosis in comparison to the referent group. Effects on humoral immunity were noted by an increase of complement component C3 and in part by an increase of immunoglobulin-G (IgG) and immunoglobulin-A (IgA). Autoimmunity phenomena were demonstrated by occurrence of antinuclear antibodies and of circulating immune complexes, containing C3, IgG, IgA, and immunoglobulin-M. These alterations occurred not only in miners where silicosis was manifest, but also in miners without radiologically detectable fibrosis. Quartz containing dusts stimulated not only those functions of the macrophages which were involved in fibrosis, but also resulted in immunoregulatory dysfunctions detectable before the incidence or independently of a clinical manifest fibrosis. As demonstrated by incidence of antinuclear antibodies, the quality of quartz containing dust has a great influence on the manifestation of autoimmunity phenomena.
• Subjects:
  Accidents, Occupational Hydrocarbons Mortality Neoplasms Nervous System Nervous System Diseases Occupational Health Personal Protective Equipment Respiratory Protective Devices Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Dust Exposure Immune Reaction Long Term Exposure Mining Industry Radiodiagnosis Respiratory System Disorders Silica Dusts
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1455-1458
• NIOSHTIC Number:
  nn:00198708
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1455-1458
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d05e3699c70a03517c22da77c6cca01cb021e5f4ec603244233128433e22e7ca2941cb136543d52900542ccbc5fd8f7bb693cf45439f114510ecc926e73dd568
• Download URL:
  https://stacks.cdc.gov/view/cdc/180621/cdc_180621_DS1.pdf
• File Type:
  [PDF - 146.27 KB ]