Do silicon-oxygen radicals play a role in the quartz-induced hemolysis and fibrogenicity?

Details

• Personal Author:
  Dalal NS ; Shi X ; Vallyathan V
• Description:
  An investigation was conducted to determine whether silicon oxygen radicals have a part in quartz (14808607) induced hemolysis and fibrogenicity. Crystalline quartz particles with a size range of 0.2 to 2.5 millimeters were crushed in air to obtain quartz dust samples with particle sizes smaller than 20 microns. Hemolytic activity of silica was measured as the amount of hemoglobin released from a 2% suspension of sheep erythrocytes after incubation with 10 milligrams of silica (7631869) dust for one hour at 37 degrees-C. Peroxidation of the polyunsaturated lipid linoleic-acid by freshly ground or aged silica was monitored using a fluorescence method. This investigation demonstrated that fracture induced silicon oxygen radicals are not directly involved in the mechanism of the erythrocyte hemolysis by quartz. The authors suggest however that these radicals may be directly or indirectly involved in an oxidative type chain reaction leading to macrophage membrane perturbation through lipid peroxidation and eventual fibrosis.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Coal Dust Mining Occupational Health Particulate Matter Safety
• Keywords:
  Airborne Particles Dust Exposure Fibrogenesis In Vitro Study Lung Irritants Mineral Dusts Quartz Dust
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1424-1428
• NIOSHTIC Number:
  nn:00198704
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1424-1428
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:18d65d4fad00fd63fc966b92023ccaee719de2776a6d42bf36c5401b69b3a46955c51013941a30b1eeb11a4c627920ced9ba0647383e65963bfd2084a1956ca8
• Download URL:
  https://stacks.cdc.gov/view/cdc/180617/cdc_180617_DS1.pdf
• File Type:
  [PDF - 202.97 KB ]