The dependence of the biological effects in rats on the physical characteristic values of intratracheally tested dusts.

Details

• Personal Author:
  Ehm W ; Rosmanith J ; Schyma SB
• Description:
  The effect of the physical properties of the coal mine dusts on their specific harmfulness were investigated. Four fractions of different size distributions from four total airborne coal mine dusts sampled on filters were characterized by means of physical methods in their dispersed state. Fifty milligrams of each dust sample were intratracheally instilled in rats as a suspension in 0.5 milliliters of saline solution. The rats were sacrificed 12 months after instillation and the amount of hydroxyproline and lipids as well as the dust mass in the lungs and lymph nodes were determined. The total hydroxyproline correlated with the surface properties of the applied dusts and the total lipids in the lungs with the surface tension of the tested solution. The total lipids were dependent on the hypothetical minimum surface per mass and were reflected by the different surface tension of the tested solution respectively. According to the thermodynamic low the surface tension tended to stop the surface of the phase in minimum. The lipid effect of the tested dusts was produced by their influence on the surfactant system of the lungs and did not reflect the fibrogenicity of the dusts.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Art Ceramics Nervous System Nervous System Diseases Occupational Health Paint Safety Solvents
• Keywords:
  Airborne Dusts Analytical Methods Cell Damage Cell Function Dust Exposure Fibrous Bodies Laboratory Animals Lung Cells Mineral Dusts Silica Dusts
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  560-565
• NIOSHTIC Number:
  nn:00198463
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Sep; (Part I):560-565
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  False
• Part Number:
  I
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3614b9247a636a76238be84cffc83d5a9c622e5ddccf987ec44172b2761e644b9f3ca889a9dff86708fb2f7aa2d1e937be341f82eb20a736fd283d55c604ba72
• Download URL:
  https://stacks.cdc.gov/view/cdc/180526/cdc_180526_DS1.pdf
• File Type:
  [PDF - 129.08 KB ]