A study on change of type I and III collagen during fibrosis induced by silica and welding fume dust.

Details

• Personal Author:
  Yu XH ; Yurui L
• Description:
  An investigation was conducted by applying the enzyme linked immunosorbent assay method to the determination of the contents and distribution of Type-I and Type-III collagen in female Wistar-rats who had been exposed to either quartz (14808607) dust or welding fume dust. The contents of Type-I and Type-III collagen in silicotic rat lung were both increased continuously as the time increased after dusting. At 10 days after dusting the ratio was about two and remained at a constant level until 90 days after dusting. Histological study of collagen fibers in the slices indicated that the alveolar septa and lung interstitial were all expanded and had accumulated Type-I and Type-III collagen. Type-III collagen predominated at 10 days after dusting with silica while at 20 days Type-I collagen was the primary one present. In the rats exposed to welding fume dust, the content of Type-III collagen was significantly greater at 30 days post exposure but there was no significant increase of Type-I collagen until about 180 days after dusting. The ratios of Type-I/Type-III collagen in the lung decreased gradually within 90 days and were raised to nearly normal levels at 180 days. The authors conclude that the type of welding fume dust used induces a slower and milder lung fibrosis when compared to silicosis.
• Subjects:
  Accidents, Occupational Anatomy Diagnosis Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Airborne Dusts Cell Damage Cell Function Dust Exposure Fibrous Bodies Laboratory Animals Lung Cells Mineral Dusts Silica Dusts Welders
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  Maine ; OSHA Region 1 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  566-570
• NIOSHTIC Number:
  nn:00198464
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Sep; (Part I):566-570
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  False
• Part Number:
  I
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d169717a30f7072b58c20e947805ce2c698bbfa9d91d1d190c4a10f90965fc33a7fbdbbc64ec45a0339a7da4c45b0f4d3eb695a81c8127cfa5ddf88581a18d89
• Download URL:
  https://stacks.cdc.gov/view/cdc/180527/cdc_180527_DS1.pdf
• File Type:
  [PDF - 136.92 KB ]