Vaccine Preventability of Meningococcal Clone, Greater Aachen Region, Germany

Elias, Johannes; Schouls, Leo M.; van de Pol, Ingrid; Keijzers, Wendy C.; Martin, Diana R.; Glennie, Anne; Oster, Philipp; Frosch, Matthias; Vogel, Ulrich; van der Ende, Arie

i

Vaccine Preventability of Meningococcal Clone, Greater Aachen Region, Germany

Supporting Files Public Domain

Mar 2010
By Elias, Johannes ; Schouls, Leo M. ; van de Pol, Ingrid ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Elias, Johannes ; Schouls, Leo M. ; van de Pol, Ingrid ; Keijzers, Wendy C. ; Martin, Diana R. ; Glennie, Anne ; Oster, Philipp ; Frosch, Matthias ; Vogel, Ulrich ; van der Ende, Arie
Description:

Emergence of serogroup B meningococci of clonal complex sequence type (ST) 41/44 can cause high levels of disease, as exemplified by a recent epidemic in New Zealand. Multiplication of annual incidence rates (3.1 cases/100,000 population) of meningococcal disease in a defined German region, the city of Aachen and 3 neighboring countries (Greater Aachen) prompted us to investigate and determine the source and nature of this outbreak. Using molecular typing and geographic mapping, we analyzed 1,143 strains belonging to ST41/44 complex, isolated from persons with invasive meningococcal disease over 6 years (2001-2006) from 2 German federal states (total population 26 million) and the Netherlands. A spatially slowly moving clone with multiple-locus variable-number tandem repeat analysis type 19, ST42, and antigenic profile B:P1.7-2,4:F1-5 was responsible for the outbreak. Bactericidal activity in serum samples from the New Zealand MeNZB vaccination campaign confirmed vaccine preventability. Because this globally distributed epidemic strain spreads slowly, vaccination efforts could possibly eliminate meningococcal disease in this area.
Subjects:

Child Child, Preschool Disease Outbreaks Humans Incidence Infant Meningococcal Infections Meningococcal Vaccines Neisseria Meningitidis Neisseria Meningitidis, Serogroup B Serum Bactericidal Test
Source:

Emerg Infect Dis. 16(3):464-472.
Document Type:

Journal Article
Place as Subject:

Germany ; Netherlands
Volume:

16
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:3ae0a3dc56280a8b5ccdc2d22d370ea4e29f4de3447b51532e840062604b86a2
Download URL:

https://stacks.cdc.gov/view/cdc/18029/cdc_18029_DS1.pdf
File Type:

[PDF - 613.85 KB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.