Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999–2007
Published Date:Feb 2010
Source:Emerg Infect Dis. 16(2):251-257.
Corporate Authors:British Columbia Cryptococcus gattii Working Group
Aged, 80 And Over
AIDS-Related Opportunistic Infections
Lung Diseases, Fungal
Description:British Columbia, Canada, has the largest reported population of Cryptococcus gattii-infected persons worldwide. To assess the impact of illness, we retrospectively analyzed demographic and clinical features of reported cases, hospitalizations, and deaths during 1999-2007. A total of 218 cases were reported (average annual incidence 5.8 per million persons). Most persons who sought treatment had respiratory illness (76.6%) or lung cryptococcoma (75.4%). Persons without HIV/AIDS hospitalized with cryptococcosis were more likely than those with HIV/AIDS to be older and admitted for pulmonary cryptococcosis. The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain. Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains. Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.
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