Actinobaculum schaalii, a Common Uropathogen in Elderly Patients, Denmark

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bank, Steffen ; Jensen, Anders ; Hansen, Thomas M. ; Søby, Karen M. ; Prag, Jørgen
• Description:
  Actinobaculum schaalii can cause urinary tract infections and septicemia but is difficult to identify by cultivation. To obtain a fast diagnosis and identify A. schaalii, we developed a TaqMan real-time quantitative PCR. Routine urine samples were obtained from 177 hospitalized patients and 75 outpatients in Viborg County, Denmark, in 2008-2009. The PCR detected A. schaalii in 22% of samples from patients >60 years of age. This assay showed that A. schaalii is more common than implied by routine cultivation. In 90% of PCR-positive urine samples, other common uropathogens were identified. This finding suggests that A. schaalii is a common, undetected, bacterial pathogen. Our results suggest that A. schaalii may be a more common pathogen than previously thought, especially in patients with unexplained chronic urinary tract infections, who are often treated with trimethoprim or ciprofloxacin, to which A. schaalii is resistant.
• Subjects:
  Actinobaculum Schaalii Actinomycetaceae Actinomycetales Infections Aged Aged, 80 And Over Age Factors Bacteria Denmark Female Humans Male Middle Aged Phylogeny Polymerase Chain Reaction Real-time PCR Research Urinary Tract Infections Urine Uropathogen

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• Source:
  Emerg Infect Dis. 16(1):76-80.
• Document Type:
  Journal Article
• Volume:
  16
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f473132c177db3fcf3bfcaefced07c1f2385370de78462f30fce05523ec6bfd0
• Download URL:
  https://stacks.cdc.gov/view/cdc/17965/cdc_17965_DS1.pdf
• File Type:
  [PDF - 212.49 KB ]