Co-carcinogenicity of foundry particulates silica and silica sand substitutes, volume 3, final report.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Data from a carcinogenicity study of foundry particulates, silica (14808607) and silica sand substitutes in hamsters are presented. Results indicated that silica sand and 10 silica sand substitutes were found not to be carcinogenic when administered by intratracheal instillation to male Syrian-Golden-hamsters. When given with benzo(a)pyrene (50328), the substances showed a definite cocarcinogenic effect in the hamster respiratory system. A tumor inventory and group and individual summaries of the histopathological findings of the study are provided. Organs and tissues examined for histopathological changes are listed. Tumors observed included squamous cell carcinomas, metastatic adenocarcinomas, polyps, cortical cell adenomas and reticular cell sarcomas. Mortality data is also provided.
• Subjects:
  • Accidents, Occupational
  • Electromagnetic Phenomena
  • Manufacturing and Industrial Facilities
  • Occupational Health
  • Personal Protective Equipment
  • Plastics
  • Preceptorship
  • Radiation
  • Radio Waves
  • Safety
  More +
• Keywords:
  • NIOSH-Contract
  • Industrial-exposures
  • Animal-studies
  • Carcinogenicity
  • Airborne-particles
  • Foundry-sands
  • Silica-dusts
  • Tumorigens
  • Histopathology
  • Mortality-data
  More +
• Document Type:
  Text
• Funding:
  Contract
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-412
• NIOSHTIC Number:
  nn:00134978
• Citation:
  Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio 1984 Mar; :1-412
• CAS Registry Number:
  • Benzoapyrene (CAS RN 50-32-8)
  • Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  False
• Source Full Name:
  Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio
• Download URL:
  https://stacks.cdc.gov/view/cdc/179648/cdc_179648_DS1.pdf
• File Type:
  [PDF - 11.70 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c60ad894bfb682e71124a13fd7ca163836111f95b7573bb75806f96a44f81ec3029be65d252077b1ba8e215a8f5a385afd6b49c80ee2f03847f5447bbbad493d