Co-carcinogenicity of foundry particulates silica and silica sand substitutes, volume 1, final report.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  A carcinogenicity assay of silica (14808607) and silica sand substitutes was conducted. Male Syrian-Golden-hamsters were administered silica sand and 10 silica sand substitutes alone or with benzo(a)pyrene (50328) (BP) by intratracheal instillation weekly for 15 weeks. Doses ranged from 0.7 to 3.0 milligrams per 77 weeks. Moribund and all surviving animals were killed after 92 weeks. Complete necropsies were conducted. The silica and silica sand substitutes were not carcinogenic to the hamster respiratory tract. When given with BP, silica sand and the substitutes, except for an aluminum (7429905) silica formulation, caused a significantly higher incidence of respiratory tumors than BP alone. Malignant tumors were induced in all parts of the respiratory tract, and consisted primarily of adenocarcinomas, adenosquamous carcinomas, squamous cell carcinomas, and adenomas. Silica and the silica sand substitutes did not induce any fibrogenic activity in the lungs. No pathological changes were seen in any other organs. The authors conclude that silica and silica sand substitutes by themselves are not carcinogenic to the hamster respiratory tract. When instilled with BP, they show a definite cocarcinogenic response.
• Subjects:
  • Accidents, Occupational
  • Health Care Facilities Workforce and Services
  • Manufacturing and Industrial Facilities
  • Occupational Health
  • Preceptorship
  • Radiation
  • Radio Waves
  • Safety
  • Staff Development
  • Surveys and Questionnaires
  More +
• Keywords:
  • NIOSH-Contract
  • Industrial-exposures
  • Animal-studies
  • Carcinogenicity
  • Airborne-particles
  • Foundry-sands
  • Silica-dusts
  • Tumorigens
  • Histopathology
  • Mortality-data
  More +
• Document Type:
  Text
• Funding:
  Contract
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-188
• NIOSHTIC Number:
  nn:00134893
• Citation:
  NIOSH 1984 Mar; :1-188
• CAS Registry Number:
  • Aluminum (CAS RN 7429-90-5)
  • Benzoapyrene (CAS RN 50-32-8)
  • Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  False
• Source Full Name:
  Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio
• Download URL:
  https://stacks.cdc.gov/view/cdc/179635/cdc_179635_DS1.pdf
• File Type:
  [PDF - 4.80 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4acbff220820d3ed639b65fab2dd3c44048e74fec07eb180157aed1e7660f9d2b4e0569f63a314f96bf7650bbc25f258863d85dfa4150ef3fe4486f5f94e65d0