Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, N,N-dimethylacetamide, report no. 27.

Details

• Personal Author:
  McGregor DB
• Description:
  The Tier II mutagenic screening of N,N-dimethylacetamide (127195) (DMA) was conducted. The unscheduled DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 70 to 9366 micrograms per milliliter DMA. A cytogenetic analysis of rat bone marrow cells was performed after in-vivo exposure to 20 or 700 parts per million (ppm) DMA for 7 hours per day for 1 or 5 days. Dominant lethal tests in male rats and sperm abnormality tests in male mice were performed after in-vivo exposure to 20 or 700ppm DMA for 7 hours per day for 5 days. The sex linked recessive lethal test was performed using Drosophila-melanogaster after a 95 minute exposure to 200ppm. DMA produced no increases in UDS, sex linked recessive lethal frequency, abnormal sperm frequency, or rat bone marrow cell DNA aberrations. No effects due to DMA exposure were observed in the dominant lethal assay. The author concludes that DMA showed no mutagenic activity under these test conditions.
• Subjects:
  Accidents, Occupational Diagnosis Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Bioassays Contract-210-78-0026 Mutagenesis NIOSH-Contract Screening-methods
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-178
• NIOSHTIC Number:
  nn:00124843
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1980 Dec; :1-178
• CAS Registry Number:
  Dimethylacetamide (CAS RN 127-19-5)
• Federal Fiscal Year:
  1981
• Performing Organization:
  Inveresk Research International Limited, Musselburgh, Scotland
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2954df56757a67ff6ab8006987d1df931d443146f47b0e0aba958fdeda38bb92cf2ee9897d24a558780e402785032fb5263150260ffbf4c4f415bc68d416e515
• Download URL:
  https://stacks.cdc.gov/view/cdc/179503/cdc_179503_DS1.pdf
• File Type:
  [PDF - 5.32 MB ]