Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, butylene oxide, report no. 28.

Details

• Personal Author:
  McGregor DB
• Description:
  The Tier II mutagenic screening of butylene-oxide (109999) (BO) was conducted. The unschedule DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 11 to 7300 micrograms per milliliter BO. A cytogenetic analysis of rat bone marrow cells was performed after in-vivo exposure to 250 or 1000 parts per million (ppm) BO for 7 hours per day for 1 or 5 days. Dominant lethal test in male rats and sperm abnormality tests in male mice were performed after in-vivo exposure to 250 or 1000ppm BO for 7 hours per day for 5 days. The sex linked recessive lethal test was performed using Drosophila-melanogaster after a 7 hour exposure to 1000ppm. BO produced no increases in UDS, sperm abnormality frequency, or sex linked recessive lethal mutation frequency. No effects due to BO exposure were observed in the dominant lethal assay. The author concludes that BO showed no mutagenic activity under these test conditions.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Air Pollution, Indoor Carcinogens Dust Glass Manufacturing And Industrial Facilities Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Bioassays Contract-210-78-0026 Mutagenesis NIOSH-Contract Screening-methods
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-187
• NIOSHTIC Number:
  nn:00124842
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1981 Feb; :1-187
• CAS Registry Number:
  Tetrahydrofuran (CAS RN 109-99-9)
• Federal Fiscal Year:
  1981
• Performing Organization:
  Inveresk Research International Limited, Musselburgh, Scotland
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:18134373415c9de1ffdf68daa0562bc9e1e95e3fe89e19d12f6470d282627a26ae84b1070791c5b284d581b5037606a60c7ca5c1dcd79392ca6b75c7106aed9f
• Download URL:
  https://stacks.cdc.gov/view/cdc/179502/cdc_179502_DS1.pdf
• File Type:
  [PDF - 5.54 MB ]