Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, bis(2-methoxyethyl) ether.

Details

• Personal Author:
  McGregor DB
• Description:
  Bis(2-methoxyethyl)-ether (111966) (BME) was subjected to a tier II mutagenic screening program. Screening assays included unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations up to 19,000 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposures to atmospheres containing 250 parts per million (ppm) or 1000ppm BME for 7 hours per day for 5 days; sperm abnormality test in male mice using the same exposures conditions; cytogenetic test in male and female rat bone marrow cells using the same exposure conditions or a single exposure of 7 hours duration; sex-linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 250ppm for 2.75 hours. There was no increase in UDS in cells treated with BME; clinical signs of toxicity occurred in animals exposed to 1000ppm BME atmospheres; male rat fertility was drastically reduced following exposure to 1000ppm BME in the dominant lethal test; a significant reduction in total aberrant cell frequency occurred; and abnormal sperm frequency was increased. The author concludes that BME may be a weak mutagen, but the adverse effect upon reproductive capacity is probably the more important aspect of its toxicology.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Insecticides Occupational Health Safety
• Keywords:
  Bioassays Contract-210-78-0026 Genetic-disorders Mutagenesis NIOSH-Contract Screening-methods Toxicology
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-185
• NIOSHTIC Number:
  nn:00123528
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1981 Jul; :1-185
• CAS Registry Number:
  Diglyme (CAS RN 111-96-6)
• Federal Fiscal Year:
  1981
• Performing Organization:
  Inveresk Research International Limited, Musselburgh, Scotland
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dd227e3ba71e1a1e3e5bb7c3c71830447e8513929aa82e43b825b23fd09c92ad43e54893b35f0f4bda0a57ec86d39b534006490e5f04485ed9f4c214684f490e
• Download URL:
  https://stacks.cdc.gov/view/cdc/179486/cdc_179486_DS1.pdf
• File Type:
  [PDF - 5.78 MB ]