Norovirus Gastroenteritis Outbreak with a Secretor-independent Susceptibility Pattern, Sweden

Details

• Journal Article:
  Emerging Infectious Diseases
• Personal Author:
  Nordgren, Johan ; Kindberg, Elin ; Lindgren, Per-Eric ; Matussek, Andreas ; Svensson, Lennart
• Description:
  Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio OR 1.41, 95% confidence interval CI 0.46-4.36 vs. OR 0.71, 95% CI 0.23-2.18, p = 0.57). Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes. The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. This norovirus outbreak affected persons regardless of secretor status or Lewis or ABO phenotypes.
• Subjects:
  • Norovirus
  • GI.3
  • ABO Blood-Group System
  • Adult
  • Base Sequence
  • Caliciviridae Infections
  • Disease Outbreaks
  • Gastroenteritis
  • Genetic Predisposition to Disease
  • Humans
  More +
• Series:
  Emerging Infectious Diseases
• Pubmed ID:
  20031047
• Document Type:
  Text ; Journal Article
• Genre:
  Journal Article
• Rights:
  Public Domain
• Volume:
  16
• Issue:
  1
• Citation:
  Emerg Infect Dis. 16(1):81-87.
• Download URL:
  https://stacks.cdc.gov/view/cdc/17935/cdc_17935_DS1.pdf
• File Type:
  [PDF - 242.22 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:63b0b2a720254fb2e88bb4d9f491f0f50f7279864e11a85c5880e19ffa23f7a776759832372c32918cdeda05cb76d36ddaeb07d9c485f854617144174a5c1159