Norovirus Gastroenteritis Outbreak with a Secretor-independent Susceptibility Pattern, Sweden
Published Date:Jan 2010
Source:Emerg Infect Dis. 16(1):81-87.
Keywords:ABO Blood-Group System
Genetic Predisposition To Disease
Histo-blood Group Antigens
Lewis Blood-Group System
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Homology, Amino Acid
Description:Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46-4.36 vs. OR 0.71, 95% CI 0.23-2.18, p = 0.57). Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes. The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. This norovirus outbreak affected persons regardless of secretor status or Lewis or ABO phenotypes.
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