Norovirus Gastroenteritis Outbreak with a Secretor-independent Susceptibility Pattern, Sweden

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nordgren, Johan ; Kindberg, Elin ; Lindgren, Per-Eric ; Matussek, Andreas ; Svensson, Lennart
• Description:
  Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46-4.36 vs. OR 0.71, 95% CI 0.23-2.18, p = 0.57). Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes. The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. This norovirus outbreak affected persons regardless of secretor status or Lewis or ABO phenotypes.
• Subjects:
  ABO Blood-Group System Adult Base Sequence Caliciviridae Infections Disease Outbreaks Enteric Infections Gastroenteritis Genetic Predisposition To Disease GI.3 Histo-blood Group Antigens Humans Lewis Blood-Group System Molecular Sequence Data Norovirus Odds Ratio Phenotype Polymerase Chain Reaction Research Saliva Sequence Homology, Amino Acid Susceptibility Sweden Viruses Virus Shedding

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• Source:
  Emerg Infect Dis. 16(1):81-87.
• Document Type:
  Journal Article
• Volume:
  16
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:2dcb31ac91c5bdfb4cf97be421dd78d687c0d82e77156563015b10a25d5c8cf6
• Download URL:
  https://stacks.cdc.gov/view/cdc/17935/cdc_17935_DS1.pdf
• File Type:
  [PDF - 242.22 KB ]