Toxicity evaluation for establishing IDLH values.

Details

• Personal Author:
  Allen SD ; Price NH ; Waters SW ; Yates WG
• Description:
  Acute whole body inhalation toxicology from exposure to the industrial chemicals 2-aminoethanol (141435), 2- (diethylamino)ethanol (100378), diisopropylamine (108189), ortho- toluidine (95534), para-anisidine (104949), ortho-anisidine (90040), Aroclor 1254 (11097691), phosgene (75445), stibine (7803523), and diazomethane (334883) was tested in groups of 10 rats and 10 guinea pigs. Concentrations which produced no effect, a minimal effect, and an irreversible pathological effect were used. Experimental methodology included the design and operation of inhalation chambers, generation of the test compound atmospheres, atmospheric sampling and analysis, and animal procurement care, and pathology. Experimental data collected from the animal exposures is presented for each chemical used and for the differing exposure concentrations. Observations used to verify the impairment of ability of the test animals to escape, animal deaths, irreversible histopathological lesions, and the differences between control and test animal organ and body weight are presented. Data for each compound are summarized by results of chemical analyses, the type of effect, and the differences between test and control animal weight data.
• Subjects:
  Accidents, Occupational Hazardous Substances Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Safety Safety Management Transportation
• Keywords:
  Air-contamination Air-quality-measurement Chemical-processing-industry Contract-210-77-0048 Laboratory-animals Measurement-instrumentation Measurement-methods NIOSH-Contract Physiological-effects Safety-measures
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-248
• NIOSHTIC Number:
  nn:00091836
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, TR 1518-005, NIOSH 1979 Apr; :1-248
• CAS Registry Number:
  Ethanolamine (CAS RN 141-43-5) ; Diethylethanolamine (CAS RN 100-37-8) ; Diisopropylamine (CAS RN 108-18-9) ; o-Toluidine (CAS RN 95-53-4) ; 4-Methoxyaniline (CAS RN 104-94-9) ; 2-Methoxyaniline (CAS RN 90-04-0) ; PCB-1254 (CAS RN 11097-69-1) ; Phosgene (CAS RN 75-44-5) ; Stibine (CAS RN 7803-52-3) ; Diazomethane (CAS RN 334-88-3)
• Federal Fiscal Year:
  1979
• Performing Organization:
  University of Utah Research Institute
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d31b88a3a20f18cd9b502b0aba062241c6cec2826ca69b8ceed5c26cfe7deaa9894f792b0de4f34c891af878fb382822f599592ea8d7437f53ff829ee66c365
• Download URL:
  https://stacks.cdc.gov/view/cdc/178927/cdc_178927_DS1.pdf
• File Type:
  [PDF - 9.09 MB ]