Acetone: development of a biologic standard for the industrial worker by breath analysis.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  In order to determine physiological responses and develop a practical biological test to indicate the magnitude of industrial exposure to acetone (67641), 20 healthy adults of both sexes were exposed to known concentrations of acetone vapor in a controlled environment chamber. Exposures consisted of both steady, nonfluctuating vapor concentrations and widely fluctuating vapor concentrations. Male subjects were exposed to acetone vapor concentrations of 0, 200, 1,000, and 1,250ppm for periods of 3 or 7.5 hours. Blood samples were taken. Various neurological and physiological tests were performed. Highly reproducible breath decay curves were obtained. Minimal variation in range of acetone in breath in identically exposed groups indicated breath analysis to be a rapid method for detection of the magnitude of recent acetone exposure and provides a biologic threshold limit. Repetitive exposure to the current threshold limit value (TLV) of 1,000ppm produced no serious health responses in healthy subjects. Changes observed in the visual evoked response of males given 1,250ppm and the possible effect of 1,000ppm on the menstrual cycle indicate that the current TLV may not afford a substantial safety margin.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Air Pollution, Indoor Mortality Occupational Exposure Occupational Health Safety Solvents Workplace
• Keywords:
  Biological-sampling Blood-sampling Blood-tests Breathing Contract-099-72-0084 NIOSH-Contract Organic-solvents Organic-vapors Reproductive-system-disorders Sensory-processes Testing Urinalysis Vision-tests Visual-performance

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• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-98
• NIOSHTIC Number:
  nn:00080673
• Citation:
  NIOSH 1975 Jun; :1-98
• CAS Registry Number:
  Acetone (CAS RN 67-64-1)
• Federal Fiscal Year:
  1975
• NORA Priority Area:
  Reproductive-system-disorders
• Performing Organization:
  The Medical College of Wisconsin, Department of Environmental Medicine
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:946a38893f5b110eee6ee18e137ff0a3970c90dddf9a102fe314eba9862d95b50961e562c41ed0f740508ce237f48b23841e4479cbc28e353478e7be81426f11
• Download URL:
  https://stacks.cdc.gov/view/cdc/178888/cdc_178888_DS1.pdf
• File Type:
  [PDF - 2.33 MB ]