Toluene: development of a biologic standard for the industrial worker by breath analysis.

Details

• Personal Author:
  Forster HV ; Hake CL ; Lebrun AJ ; Peterson J ; Stewart RD ; Wu A
• Description:
  A comprehensive study to determine the biologic threshold limit value of toluene (108883) utilizing the breath analysis decay curve (BADC) was conducted. Twenty healthy adults were exposed to vapor concentrations in an environmentally controlled chamber. The exposure consisted of both steady nonfluctuating concentrations as well as widely fluctuating concentrations. Eleven male subjects were exposed to 0, 20, 50, and 100ppm toluene for 1, 3 or 7.5 hr. Female subjects were exposed to 100ppm for 1, 3 or 7.5 hr. Breath and urine samples were taken. Neurological studies, cardiopulmonary function tests, and cognitive testing were performed. Subjects exposed to toluene at 100ppm for 7.5 hr/day, 5 day/wk demonstrated deleterious effects on visual-evoked-response, increased errors in an alertness test and irritation of the nasal-mucosa. Subjects at 100ppm 3 hr/day, 5 day/wk noted an increase in eye, nose, and throat irritation. Blood-levels were relatively constant at exposures of 50 and 100ppm. Hippuric-acid (495692) excretion increased in a dose dependent manner. The biologic threshold limit value for toluene workers is suggested to be the upper limit of the range of BADC of those exposed 7.5 hr/day for 5 days.
• Subjects:
  Accidents, Occupational Occupational Health Personal Protective Equipment Respiratory Protective Devices Safety
• Keywords:
  Aromatic-hydrocarbons Behavioral-tests Biological-sampling Blood-sampling Blood-tests Contract-099-72-0084 Eye-irritants Irritants NIOSH-Contract Organic-solvents Organic-vapors Respiratory-irritants Sampling Standards Testing Urinalysis Vapor-volume Vision-test Visual-performance Visual-stimulation

  More +
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-78
• NIOSHTIC Number:
  nn:00080663
• Citation:
  NIOSH 1975 Feb; :1-78
• CAS Registry Number:
  Toluene (CAS RN 108-88-3) ; Hippuric acid (CAS RN 495-69-2)
• Federal Fiscal Year:
  1975
• Performing Organization:
  The Medical College of Wisconsin, Department of Environmental Medicine
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:924bc633e52f7b69528a2976e10bfff060abe2515165ccba2429dda66425ae6bcd91d38ba04e12ba175d1608218c34c824121456ec470531443b7615b442cac9
• Download URL:
  https://stacks.cdc.gov/view/cdc/178884/cdc_178884_DS1.pdf
• File Type:
  [PDF - 2.72 MB ]