Healthcare-associated Viral Gastroenteritis among Children in a Large Pediatric Hospital, United Kingdom

Cunliffe, Nigel A.; Booth, J. Angela; Elliot, Claire; Lowe, Sharon J.; Sopwith, Will; Kitchin, Nick; Nakagomi, Osamu; Nakagomi, Toyoko; Hart, C. Anthony; Regan, Martyn

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Healthcare-associated Viral Gastroenteritis among Children in a Large Pediatric Hospital, United Kingdom

Supporting Files Public Domain

Jan 2010
By Cunliffe, Nigel A. ; Booth, J. Angela ; Elliot, Claire ; ...
Series: Emerging Infectious Diseases

File Language:

English

Details

Journal Article:

Emerging Infectious Diseases
Personal Author:

Cunliffe, Nigel A. ; Booth, J. Angela ; Elliot, Claire ; Lowe, Sharon J. ; Sopwith, Will ; Kitchin, Nick ; Nakagomi, Osamu ; Nakagomi, Toyoko ; Hart, C. Anthony ; Regan, Martyn
Description:

Viruses are the major pathogens of community-acquired (CA) acute gastroenteritis (AGE) in children, but their role in healthcare-associated (HA) AGE is poorly understood. Children with AGE hospitalized at Alder Hey Children's Hospital, Liverpool, UK, were enrolled over a 2-year period. AGE was classified as HA if diarrhea developed > or =48 hours after admission. Rotavirus, norovirus, adenovirus 40/41, astrovirus, and sapovirus were detected by PCR. A total of 225 children with HA-AGE and 351 with CA-AGE were enrolled in the study. HA viral gastroenteritis constituted one fifth of the diarrheal diseases among hospitalized children and commonly occurred in critical care areas. We detected > or =1 virus in 120 (53%) of HA-AGE cases; rotavirus (31%), norovirus (16%), and adenovirus 40/41 (15%) were the predominant viruses identified. Molecular evidence indicated rotaviruses and noroviruses were frequently introduced into the hospital from the community. Rotavirus vaccines could substantially reduce the incidence of HA-AGE in children.
Subjects:

Caliciviridae Infections Child Child, Preschool Cross Infection Gastroenteritis Genotype Great Britain Hospital Bed Capacity, 300 To 499 Hospitals, Pediatric Humans Infant Norovirus Phylogeny Polymerase Chain Reaction Rotavirus Rotavirus Infections
Series:

Emerging Infectious Diseases
Publisher:

Centers for Disease Control and Prevention (CDC) (U.S.)
Pubmed ID:

20031043
Document Type:

Text ; Journal Article
Genre:

Journal Article
Rights:

Public Domain
Volume:

16
Issue:

1
Citation:

Emerg Infect Dis. 16(1):55-62.
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:5b5641a0aac1ec0eeba5d7fa62e7d81b9c4ab6bd7d18e10069583f5894ebbb8566a4f1bdeab067d296673fee31d434924de2c6b300bc356c09b35df4246471d9
Download URL:

https://stacks.cdc.gov/view/cdc/17888/cdc_17888_DS1.pdf
File Type:

[PDF - 339.47 KB ]

File Language:

English

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