Healthcare-associated Viral Gastroenteritis among Children in a Large Pediatric Hospital, United Kingdom

Cunliffe, Nigel A.; Booth, J. Angela; Elliot, Claire; Lowe, Sharon J.; Sopwith, Will; Kitchin, Nick; Nakagomi, Osamu; Nakagomi, Toyoko; Hart, C. Anthony; Regan, Martyn

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Healthcare-associated Viral Gastroenteritis among Children in a Large Pediatric Hospital, United Kingdom

Supporting Files Public Domain

Jan 2010
By Cunliffe, Nigel A. ; Booth, J. Angela ; Elliot, Claire ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Cunliffe, Nigel A. ; Booth, J. Angela ; Elliot, Claire ; Lowe, Sharon J. ; Sopwith, Will ; Kitchin, Nick ; Nakagomi, Osamu ; Nakagomi, Toyoko ; Hart, C. Anthony ; Regan, Martyn
Description:

Viruses are the major pathogens of community-acquired (CA) acute gastroenteritis (AGE) in children, but their role in healthcare-associated (HA) AGE is poorly understood. Children with AGE hospitalized at Alder Hey Children's Hospital, Liverpool, UK, were enrolled over a 2-year period. AGE was classified as HA if diarrhea developed > or =48 hours after admission. Rotavirus, norovirus, adenovirus 40/41, astrovirus, and sapovirus were detected by PCR. A total of 225 children with HA-AGE and 351 with CA-AGE were enrolled in the study. HA viral gastroenteritis constituted one fifth of the diarrheal diseases among hospitalized children and commonly occurred in critical care areas. We detected > or =1 virus in 120 (53%) of HA-AGE cases; rotavirus (31%), norovirus (16%), and adenovirus 40/41 (15%) were the predominant viruses identified. Molecular evidence indicated rotaviruses and noroviruses were frequently introduced into the hospital from the community. Rotavirus vaccines could substantially reduce the incidence of HA-AGE in children.
Subjects:

Caliciviridae Infections Child Child, Preschool Children Cross Infection Gastroenteritis Genotype Great Britain Hospital Bed Capacity, 300 To 499 Hospitals, Pediatric Humans Infant Molecular Norovirus Nosocomial Phylogeny Polymerase Chain Reaction Research Rotavirus Rotavirus Infections UK Vaccine Viruses
Source:

Emerg Infect Dis. 16(1):55-62.
Document Type:

Journal Article
Volume:

16
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:3a6d99b0e899540add56e3b4c4cb97965dee5b6f2f342d4a0cbe943ce0ef1e6c
Download URL:

https://stacks.cdc.gov/view/cdc/17888/cdc_17888_DS1.pdf
File Type:

[PDF - 339.47 KB ]

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