Toxicology of lead on kidney and other organs.

Details

• Personal Author:
  Goyer RA
• Description:
  The pathological effects of lead (7439921) on the kidney are reviewed, and evidence is given showing a possible decrease in the ability of individuals with chronic lead nephropathy to excrete lead and showing the possibilities of the role of alcohol (64175), nutrition and other metabolic factors in altering susceptibility to lead toxicity. The review includes stages of lead nephropathy, and photomicrographs of cytopathology in kidney cells involving mitochondrial changes, nuclear inclusion bodies, effects of EDTA (60004) therapy, vacuoles in the cytoplasm and interstitial fibrosis. The evidence of lower urinary lead excretion in chronic compared with acute lead nephropathy is taken from five ship wreckers. The evidence for increased susceptibility to lead toxicity is taken from a case of lead poisoning symptoms developing in a retired man who had worked near lead smelters after repeated, severe episodes of acute alcoholism and poor nutrition.
• Subjects:
  • Accidents, Occupational
  • Bibliography
  • Occupational Health
  • Safety
• Keywords:
  • NIOSH-Author
  • NIOSH-Contract
  • Contract-210-75-0026
  • Toxic-substances
  • Heavy-metals
  • Cell-alteration
  • Intracellular-alteration
  • Kidney-disorders
  • Renal-toxicity
  • Cytotoxicity
  More +
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  Illinois ; Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  86-96
• NIOSHTIC Number:
  nn:00056290
• Citation:
  Health effects of occupational lead and arsenic exposure, a symposium, Carnow BW, ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-134, 1976 Feb; :86-96
• CAS Registry Number:
  • Ethanol (CAS RN 64-17-5)
  • Ethylenediaminetetraacetic acid (CAS RN 60-00-4)
  • Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  False
• Download URL:
  https://stacks.cdc.gov/view/cdc/178771/cdc_178771_DS1.pdf
• File Type:
  [PDF - 1.61 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7f2d10ace4afe11aab85ccfef485ebda3db827b3ffdf2f87b86c2ae5948db2244ae3f1399d318e2d66da1e963bcc996432100d3bf385310e6d283cd25698ac7d