Environmental arsenic toxicology.

Details

• Personal Author:
  Fowler B
• Description:
  The mechanisms of inorganic arsenic (7440382) toxicity to cellular respiratory systems are discussed in light of previously reported data and preliminary data from an unpublished study. An electron micrograph is given of a proximal tubule cell from the kidney of a rat exposed to 85 ppm of arsenate, and data are given on respiratory parameters of mitochondria from rats and on arsenic in kidneys of rats given drinking water containing arsenate or arsenite for 14 weeks. Arsenite is shown to accumulate in higher levels in the kidneys than arsenate, which is considered less toxic to cellular respiration. The mechanism of hemolysis by arsine gas is considered related to an oxidized metabolite such as arsenious-acid. It is concluded that the toxicity of inorganic arsenic is highly dependent upon its chemical form and oxidation state.
• Subjects:
  • Accidents, Occupational
  • Dust
  • Hazardous Substances
  • Manufacturing and Industrial Facilities
  • Mining
  • Musculoskeletal Diseases
  • Occupational Health
  • Safety
• Keywords:
  • NIOSH-Author
  • NIOSH-Contract
  • Contract-210-75-0026
  • Toxic-substances
  • Heavy-metals
  • Kidney-disorders
  • Biochemical-mechanisms
  • Biochemical-reactions
  • Renal-toxicity
  • Intracellular-alteration
  More +
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  Illinois ; Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  248-252
• NIOSHTIC Number:
  nn:00056247
• Citation:
  Health effects of occupational lead and arsenic exposure, a symposium, Carnow BW, ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-134, 1976 Feb; :248-252
• CAS Registry Number:
  • Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  False
• Download URL:
  https://stacks.cdc.gov/view/cdc/178741/cdc_178741_DS1.pdf
• File Type:
  [PDF - 1.01 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:13f7389faffd9d57ca04c0464229c8f3710503fee76306de097036ece0078b80f42c01f694c0a8212f349e53a2e4aeb43f426b14c1be52a3233f30ad040680a4