Evolution of Northeastern and Midwestern Borrelia burgdorferi, United States

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Brisson, Dustin ; Vandermause, Mary F. ; Meece, Jennifer K. ; Reed, Kurt D. ; Dykhuizen, Daniel E.
• Description:
  The per capita incidence of human Lyme disease in the northeastern United States is more than twice that in the Midwest. However, the prevalence of Borrelia burgdorferi, the bacterium that causes Lyme disease, in the tick vector is nearly identical in the 2 regions. The disparity in human Lyme disease incidence may result from a disparity in the human invasiveness of the bacteria in the Northeast and Midwest caused by fundamentally different evolutionary histories. B. burgdorferi populations in the Northeast and Midwest are geographically isolated, enabling evolutionary divergence in human invasiveness. However, we found that B. burgdorferi populations in the Northeast and Midwest shared a recent common ancestor, which suggests that substantial evolutionary divergence in human invasiveness has not occurred. We propose that differences in either animal ecology or human behavior are the root cause of the differences in human incidence between the 2 regions.
• Subjects:
  Animals Antigens, Bacterial Antigens, Surface Arachnid Vectors Bacterial Outer Membrane Proteins Bacterial Vaccines DNA, Bacterial Evolution, Molecular Genetic Variation Humans Lipoproteins Lyme Disease Phylogeny Prevalence Recombination, Genetic Research RNA, Ribosomal Ticks Virulence

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• Source:
  Emerg Infect Dis. 16(6):911-917.
• Document Type:
  Journal Article
• Funding:
  AI076342/AI/NIAID NIH HHS/United States ; GM31912/GM/NIGMS NIH HHS/United States ; R01 GM060731-09/GM/NIGMS NIH HHS/United States ; U01CK000170/CK/NCEZID CDC HHS/United States
• Place as Subject:
  Midwestern United States ; New England
• Location:
  North America ; Europe
• Volume:
  16
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8511aa245fd2e1c29d6a783a1ff02a7f550de5c53475653395bc9f347deb0385
• Download URL:
  https://stacks.cdc.gov/view/cdc/17872/cdc_17872_DS1.pdf
• File Type:
  [PDF - 298.81 KB ]