Long-term inhalation reproductive and teratogenic toxicity evaluation of nitrous oxide plus halothane. Final report.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Report on the long term effects of exposure to nitrous-oxide plus halothane on the reproductive performance of female rats and the developmental processes in their offspring. Exposure of mated female rats to the combinations of nitrous-oxide (10024972) and halothane (151677) results in reduced ovulation and implantation efficiency at the higher level of exposure during the first six days after mating and a slightly retarded development of the fetuses at both levels of exposure. Exposure to 10 parts per million (ppm) of halothane plus 500 ppm of nitrous-oxide can cause toxic effects on reproduction in rats, which should be of concern to humans.
• Subjects:
  Accidents, Occupational Dust Metal Workers Occupational Exposure Occupational Health Safety
• Keywords:
  Anesthetics Brominated-hydrocarbons Contract-099-74-0046 Fluorinated-hydrocarbons Genetic-disorders Halogenated-hydrocarbons NIOSH-Contract Reproductive-system-disorders Teratogenicity Toxic-gases Toxicity

  More +
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  OSHA Region 3 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-21
• NIOSHTIC Number:
  nn:00051968
• Citation:
  NIOSH 1975 Nov; :1-21
• CAS Registry Number:
  Nitrous oxide (CAS RN 10024-97-2) ; (±)-Halothane (CAS RN 151-67-7)
• Federal Fiscal Year:
  1976
• NORA Priority Area:
  Reproductive-system-disorders
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4da974ba448da4d8a7389e9e7f07865908e05babbdadf48e34dc71e746ee5bdff5c1acf54d51183a56a38d3f034d66fc1fc7ad0ee242709263eeed930fd9d349
• Download URL:
  https://stacks.cdc.gov/view/cdc/178697/cdc_178697_DS1.pdf
• File Type:
  [PDF - 727.74 KB ]