Molecular Model of Prion Transmission to Humans

Jones, Michael; Wight, Darren; Barron, Rona; Jeffrey, Martin; Manson, Jean; Prowse, Christopher; Ironside, James W.; Head, Mark W.

doi:10.3201/eid1512.090194

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Molecular Model of Prion Transmission to Humans

Published Date:

Dec 2009

Publisher's site:

http://dx.doi.org/10.3201/eid1512.090194 New Site Icon

Source:

Emerg Infect Dis. 15(12):2013-2016.

[PDF - 521.72 KB]

Details:

Personal Authors:

Jones, Michael ; Wight, Darren ; Barron, Rona ; Jeffrey, Martin ; Manson, Jean ; ... More ▼

Keywords:

[+]

Description:

To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Funding:

G0900580/Medical Research Council/United Kingdom

Supporting Files:

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