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Molecular Model of Prion Transmission to Humans
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    Mestre-Francés, Nadine; Nicot, Simon; Rouland, Sylvie; Biacabe, Anne-Gaëlle; Quadrio, Isabelle; Perret-Liaudet, Armand; Baron, Thierry; Verdier, Jean-Michel;
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    Emerg Infect Dis. 18(1):142-145.
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  2. Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
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    To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to p...
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  3. Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease
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    Emerg Infect Dis. 18(12):2028-2031.
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    We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein-transgenic mouse line and isolated distinct p...
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  4. Susceptibility of Human Prion Protein to Conversion by Chronic Wasting Disease Prions
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    Barria, Marcelo A.; Libori, Adriana; Mitchell, Gordon; Head, Mark W.;
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    Emerg Infect Dis. 24(8):1482-1489
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    Chronic wasting disease (CWD) is a contagious and fatal neurodegenerative disease and a serious animal health issue for deer and elk in North America. The identification of the first cases of CWD among free-ranging reindeer and moose in Europe brings...
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  5. Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
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    Holznagel, Edgar; Yutzy, Barbara; Schulz-Schaeffer, Walter; Kruip, Carina; Hahmann, Uwe; Bierke, Pär; Torres, Juan-Maria; Kim, Yong-Sun; Thomzig, Achim; Beekes, Michael; Hunsmann, Gerhard; Loewer, Johannes;
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    Emerg Infect Dis. 19(5):712-720.
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    Risk for human exposure to bovine spongiform encephalopathy (BSE)-inducing agent was estimated in a nonhuman primate model. To determine attack rates, incubation times, and molecular signatures, we orally exposed 18 macaques to 1 high dose of brain m...
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