Molecular Model of Prion Transmission to Humans

Jones, Michael; Wight, Darren; Barron, Rona; Jeffrey, Martin; Manson, Jean; Prowse, Christopher; Ironside, James W.; Head, Mark W.

doi:10.3201/eid1512.090194

i

Molecular Model of Prion Transmission to Humans

Supporting Files

Dec 2009
By Jones, Michael ; Wight, Darren ; Barron, Rona
http://dx.doi.org/10.3201/eid1512.090194

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Jones, Michael ; Wight, Darren ; Barron, Rona ; Jeffrey, Martin ; Manson, Jean ; Prowse, Christopher ; Ironside, James W. ; Head, Mark W.
Description:

To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
Subjects:
Source:

Emerg Infect Dis. 15(12):2013-2016.
Document Type:

Journal Article
Funding:

G0900580/Medical Research Council/United Kingdom
Volume:

15
Issue:

12
Download URL:

https://stacks.cdc.gov/view/cdc/17533/cdc_17533_DS1.pdf
File Type:

[PDF - 521.72 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:161a4ed237f72d609ed2e2a5cf514b77f59e1b0fc4ed0e8aae9d4b909599505c

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