Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1512.090194
Personal Author:
Jones, Michael ; Wight, Darren ; Barron, Rona ; Jeffrey, Martin ; Manson, Jean ; ... More +
Jones, Michael ; Wight, Darren ; Barron, Rona ; Jeffrey, Martin ; Manson, Jean ; Prowse, Christopher ; Ironside, James W. ; Head, Mark W. ; Less -
Description:
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
Subject:
[+]
Amino Acid Sequence
Animals
Blotting, Western
Conformation
Disease Susceptibility
Disease Transmission
Dispatch
Humans
Mice
Model System
Molecular Characteristics
Prion Diseases
Prions
Protein Folding
Protein Isoforms
Protein Misfolding Cyclic Amplification
Transmissible Spongiform Encephalopathy
Dispatch

Source:
Emerg Infect Dis. 15(12):2013-2016. ;
Document Type:
Journal Article ;
Funding:
G0900580/Medical Research Council/United Kingdom ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:161a4ed237f72d609ed2e2a5cf514b77f59e1b0fc4ed0e8aae9d4b909599505c
File Type:

Supporting Files

• 	09-0194-F1.gif	gif
  	09-0194-F1.jpg	jpeg
  	09-0194-F2.gif	gif
  	09-0194-F2.jpg	jpeg
  	09-0194_finalD.nxml	txt
  	license.txt	txt

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