Molecular Model of Prion Transmission to Humans

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Jones, Michael ; Wight, Darren ; Barron, Rona ; Jeffrey, Martin ; Manson, Jean ; Prowse, Christopher ; Ironside, James W. ; Head, Mark W.
• Description:
  To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
• Subjects:
  Amino Acid Sequence Animals Blotting, Western Conformation Disease Susceptibility Disease Transmission Dispatch Humans Mice Model System Molecular Characteristics Prion Diseases Prions Protein Folding Protein Isoforms Protein Misfolding Cyclic Amplification Transmissible Spongiform Encephalopathy

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• Source:
  Emerg Infect Dis. 15(12):2013-2016.
• Document Type:
  Journal Article
• Funding:
  G0900580/Medical Research Council/United Kingdom
• Volume:
  15
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:161a4ed237f72d609ed2e2a5cf514b77f59e1b0fc4ed0e8aae9d4b909599505c
• Download URL:
  https://stacks.cdc.gov/view/cdc/17533/cdc_17533_DS1.pdf
• File Type:
  [PDF - 521.72 KB ]