Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Meade-White, Kimberly D. ; Barbian, Kent D. ; Race, Brent ; Favara, Cynthia ; Gardner, Don ; ... More +
Meade-White, Kimberly D. ; Barbian, Kent D. ; Race, Brent ; Favara, Cynthia ; Gardner, Don ; Taubner, Lara ; Porcella, Stephen ; Race, Richard ; Less -
Description:
Transmissible spongiform encephalopathy (TSE) diseases are known to cross species barriers, but the pathologic and biochemical changes that occur during transmission are not well understood. To better understand these changes, we infected 6 hamster species with 263K hamster scrapie strain and, after each of 3 successive passages in the new species, analyzed abnormal proteinase K (PK)-resistant prion protein (PrPres) glycoform ratios, PrPres PK sensitivity, incubation periods, and lesion profiles. Unique 263K molecular and biochemical profiles evolved in each of the infected hamster species. Characteristics of 263K in the new hamster species seemed to correlate best with host factors rather than agent strain. Furthermore, 2 polymorphic regions of the prion protein amino acid sequence correlated with profile differences in these TSE-infected hamster species.
Subject:
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Amino Acid Sequence
Animals
Biochemical Profile
Cricetinae
Endopeptidase K
Hamsters
Immunohistochemistry
Molecular Profile
Molecular Sequence Data
Prion Diseases
Prions
PRNP Amino Acid Sequence
Prnp Nucleotide Sequence
PrPSc Proteins
Research
Scrapie
Sequence Analysis, DNA
Serial Passage
Species Barriers
Species Specificity
Transmissible Spongiform Encephalopathy
TSE

Source:
Emerg Infect Dis. 15(2):207-215. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:cfb8854b226b8e7f28fdf7feaf7b3e9792aa45305e5e221c9c6b0c6671d9095d
File Type:

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