Slave Trade and Hepatitis B Virus Genotypes and Subgenotypes in Haiti and Africa

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Andernach, Iris E. ; Nolte, Claudine ; Pape, Jean W. ; Muller, Claude P.
• Description:
  In Haiti, >90% of the population descended from African slaves. Of 7,147 Haitian pregnant women sampled, 44% of hepatitis B virus (HBV) infections were caused by genotype A1, which today is found mainly in eastern Africa. Twenty percent belong to a rare subgenotype, A5, which has been found only in the former Bight of Benin, a former primary slave trading post. Haitian A subgenotypes appear to have separated early from the African subgenotypes; the most prevalent genotype and subgenotype in West Africa today (E and A3, respectively) are rare in Haiti. This difference indicates that the dominant subgenotypes in Africa emerged in the general population only after the slave trade and explains the low genetic diversity of genotype E. The high prevalence of HBV genotype E in much of Africa further suggests that HBV hyperendemicity is a recent phenomenon, probably resulting from extensive use of unsafe needles.
• Subjects:
  Communicable Diseases, Emerging DOI: 10.3201/eid1508.081642 Female Genotype Hepatitis B Hepatitis B Virus Humans Molecular Epidemiology Phylogeny Pregnancy Pregnancy Complications, Infectious Prevalence Recombination, Genetic Research Social Problems Transatlantic Slave Trade Viruses

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• Source:
  Emerg Infect Dis. 15(8):1222-1228.
• Document Type:
  Journal Article
• Place as Subject:
  Haiti ; Caribbean Region ; Africa
• Location:
  Caribbean ; Africa
• Volume:
  15
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dcf5517f09de53431169a837f8e7382cb937ab1a91a7b1af38cdc80a02965f3e
• Download URL:
  https://stacks.cdc.gov/view/cdc/17496/cdc_17496_DS1.pdf
• File Type:
  [PDF - 564.97 KB ]