History of COVID-19 and Overall Survival Among Medicare Beneficiaries Hospitalized with Acute Ischemic Stroke, Medicare Cohort 2020-2021
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History of COVID-19 and Overall Survival Among Medicare Beneficiaries Hospitalized with Acute Ischemic Stroke, Medicare Cohort 2020-2021

Filetype[PDF-215.53 KB]


English

Details:

  • Alternative Title:
    Austin J Cardiovasc Dis Atheroscler
  • Personal Author:
  • Description:
    Background:

    COVID-19 is associated with increased risk of Acute Ischemic Stroke (AIS). The present study examined the impact of prior COVID-19 diagnoses on overall survival among older AIS patients.

    Methods:

    We included 250,079 Medicare Fee-For-Service (FFS) beneficiaries aged ≥65 years with AIS hospitalizations from 04/01/2020 through 12/31/2021. Overall survival was defined as the time from date of AIS hospitalization to date of death, or through end of follow-up on 03/31/2023. We used a Cox proportional hazard model to examine the association between history of COVID-19 and overall survival among AIS beneficiaries, and we obtained age, sex, race/ethnicity, Social Vulnerability Index (SVI), National Institutes of Health Stroke Scale score, and comorbidity-adjusted survival estimates.

    Results:

    Among 250,079 Medicare FFS beneficiaries with AIS, 98,327 (39.3%) died during a median of 590 days (IQR, 169–819 days) of follow-up with a total of 365,606 person-years. The 1-year adjusted overall survival was 62.0%, 67.4%, and 68.8% in beneficiaries with hospitalized COVID-19, with non-hospitalized COVID-19 and no COVID-19 respectively (p<0.001). Compared to AIS without history of COVID-19, the adjusted mortality hazard ratios were 1.30 (95% CI, 1.26–1.34) and 1.06 (95% CI, 1.03–1.10) for those with a history of hospitalized and non-hospitalized COVID-19, respectively. The patterns of overall survival by COVID-19 history were largely consistent across age groups, sex, race/ethnicity, and SVI groups.

    Conclusions:

    A history of COVID-19 diagnoses, especially with a history of severe COVID-19, was associated with a significantly higher risk of all-cause mortality among Medicare FFS beneficiaries hospitalized with AIS.

  • Keywords:
  • Source:
  • Pubmed ID:
    39664321
  • Pubmed Central ID:
    PMC11633309
  • Document Type:
  • Funding:
  • Volume:
    11
  • Issue:
    1
  • Collection(s):
  • Main Document Checksum:
  • Download URL:
  • File Type:

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