Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Venter, Marietjie ; Human, Stacey ; Zaayman, Dewald ; Gerdes, Gertruida H. ; Williams, June ; ... More +
Venter, Marietjie ; Human, Stacey ; Zaayman, Dewald ; Gerdes, Gertruida H. ; Williams, June ; Steyl, Johan ; Leman, Patricia A. ; Paweska, Janusz Tadeusz ; Setzkorn, Hildegard ; Rous, Gavin ; Murray, Sue ; Parker, Rissa ; Donnellan, Cynthia ; Swanepoel, Robert Less -
Description:
Serologic evidence suggests that West Nile virus (WNV) is widely distributed in horses in southern Africa. However, because few neurologic cases have been reported, endemic lineage 2 strains were postulated to be nonpathogenic in horses. Recent evidence suggests that highly neuroinvasive lineage 2 strains exist in humans and mice. To determine whether neurologic cases are being missed in South Africa, we tested 80 serum or brain specimens from horses with unexplained fever (n = 48) and/or neurologic signs (n = 32) for WNV. From March 2007 through June 2008, using reverse transcription-PCR (RT-PCR) and immunoglobulin (Ig) M ELISA, we found WNV RNA or IgM in 7/32 horses with acute neurologic disease; 5 horses died or were euthanized. In 5/7 horses, no other pathogen was detected. DNA sequencing for all 5 RT-PCR-positive cases showed the virus belonged to lineage 2. WNV lineage 2 may cause neurologic disease in horses in South Africa.
Subject:
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Animals
Antibodies, Viral
Brain
Disease Outbreaks
Horse Diseases
Horses
Immunoglobulin M
Phylogeny
Research
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
Sequence Analysis, DNA
West Nile Fever
West Nile Virus

Source:
Emerg Infect Dis. 15(6):877-884.
Document Type:
Journal Article
Place as Subject:
South Africa
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:24c6672699bb8f98d97a410c4ef509aa484c74ec3ced2be41123848b991dc1b4
File Type:

Supporting Files

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