Multidrug- and Extensively Drug-Resistant Tuberculosis, Germany

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Eker, Barbara ; Ortmann, Johannes ; Migliori, Giovanni B. ; Sotgiu, Giovanni ; Muetterlein, Ralf ; Centis, Rosella ; Hoffmann, Harald ; Kirsten, Detlef ; Schaberg, Tom ; Ruesch-Gerdes, Sabine ; Lange, Christoph
• Corporate Authors:
  German TBNET Group
• Description:
  We evaluated risk factors and treatment outcomes associated with multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) in Germany in 2004-2006. In 177 (4%) of 4,557 culture-positive TB cases, Mycobacterium tuberculosis isolates were identified as MDR TB; an additional 7 (0.15%) met criteria for XDR TB. Of these 184 patients, 148 (80%) were born in countries of the former Soviet Union. In patients with XDR TB, hospitalization was longer (mean +/- SD 202 +/- 130 vs. 123 +/- 81 days; p = 0.015) and resistance to all first-line drugs was more frequent (36% vs. 86%; p = 0.013) than in patients with MDR TB. Seventy-four (40%) of these 184 patients received treatment with linezolid. Treatment success rates ranged from 59% for the entire cohort (59% for MDR TB and 57% for XDR TB) to 87% for those with a definitive outcome (n = 125; 89% for MDR TB and 80% for XDR TB). Extensive drug susceptibility testing and availability of second- and third-line drugs under inpatient management conditions permit relatively high treatment success rates in MDR- and XDR TB.
• Subjects:
  Acetamides Adult Antitubercular Agents Cohort Studies Drug Resistance, Multiple, Bacterial Emigrants And Immigrants Extensively Drug-Resistant Tuberculosis Female Humans Linezolid Male Mycobacterium Tuberculosis Oxazolidinones Retrospective Studies Risk Factors Sentinel Surveillance Treatment Outcome Tuberculosis, Multidrug-Resistant

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• Source:
  Emerg Infect Dis. 14(11):1700-1706
• Pubmed ID:
  18976552
• Pubmed Central ID:
  PMC2630755
• Document Type:
  Journal Article
• Place as Subject:
  Germany
• Volume:
  14
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b5c7939acf30bec4a285588224e9496f0b6b877d63fb60ad260ea02afbd9f330
• Download URL:
  https://stacks.cdc.gov/view/cdc/17343/cdc_17343_DS1.pdf
• File Type:
  [PDF - 120.19 KB ]