Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans

Drexler, Jan Felix; de Souza Luna, Luciano Kleber; Stöcker, Andreas; Almeida, Patrícia Silva; Ribeiro, Tereza Cristina Medrado; Petersen, Nadine; Herzog, Petra; Pedroso, Célia; Huppertz, Hans Iko; da Costa Ribeiro, Hugo; Baumgarte, Sigrid; Drosten, Christian

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans

Published Date:

Sep 2008

Source:

Emerg Infect Dis. 14(9):1398-1405.

[PDF - 251.07 KB]

Details:

Personal Authors:

Drexler, Jan Felix ; de Souza Luna, Luciano Kleber ; Stöcker, Andreas ; Almeida, Patrícia Silva ; Ribeiro, Tereza Cristina Medrado ; ... More ▼

Keywords:

[+]

Description:

Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis-like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients <6 years of age. Viral loads were 283,305-5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%-77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

08-0570-F1.gif	image/gif
08-0570-F1.jpg	image/jpeg
08-0570-F2.gif	image/gif
08-0570-F2.jpg	image/jpeg
08-0570_finalR.nxml	text/plain
license.txt	text/plain

No Related Documents.

You May Also Like:

Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China

Personal Author:

Ren, Lili; Gonzalez, Richard; Xie, Zhengde; Xiao, Yan; Li, Yongjun; Liu, Chunyan; Chen, Lan; Yang, Qingqing; Vernet, Guy; Paranhos-Baccalà, Gláucia; Jin, Qi; Shen, Kunling; Wang, Jianwei;

Published:

Jul 2010

Source:

Emerg Infect Dis. 16(7):1158-1161.

Description:

To clarify the potential for respiratory transmission of Saffold cardiovirus (SAFV) and characterize the pathogen, we analyzed respiratory specimens from 1,558 pediatric patients in Beijing. We detected SAFV in 7 (0.5%) patients and identified lineag...

File Type:

[PDF - 388.35 KB]
Seroepidemiology of Saffold Cardiovirus Type 2

Personal Author:

Galama, Jochem; Lanke, Kjerstin; Zoll, Jan; Roivainen, Merja; van Kuppeveld, Frank;

Published:

Aug 2011

Source:

Emerg Infect Dis. 17(8):1572-1573.

File Type:

[PDF - 86.62 KB]
New Saffold Cardiovirus in Children, China

Personal Author:

Xu, Zi-Qian; Cheng, Wei-Xia; Qi, Hong-Mei; Cui, Shu-Xian; Jin, Yu; Duan, Zhao-Jun;

Published:

Jun 2009

Source:

Emerg Infect Dis. 15(6):993-994.

File Type:

[PDF - 387.38 KB]
Circulation of Reassortant Influenza A(H7N9) Viruses in Poultry and Humans, Guangdong Province, China, 2013

Personal Author:

Ke, Changwen; Lu, Jing; Wu, Jie; Guan, Dawei; Zou, Lirong; Song, Tie; Yi, Lina; Zeng, Xianqiao; Liang, Lijun; Ni, Hanzhong; Kang, Min; Zhang, Xin; Zhong, Haojie; He, Jianfeng; Lin, Jinyan; Smith, Derek; Burke, David; Fouchier, Ron A.M.; Koopmans, Marion; Zhang, Yonghui;

Published:

Dec 2014

Source:

Emerg Infect Dis. 20(12):2034-2040.

Description:

Influenza A(H7N9) virus emerged in eastern China in February 2013 and continues to circulate in this region, but its ecology is poorly understood. In April 2013, the Guangdong Provincial Center for Disease Control and Prevention (CDC) implemented env...

File Type:

[PDF - 980.16 KB]
Co-Circulation and Persistence of Genetically Distinct Saffold Viruses, Denmark

Personal Author:

Nielsen, Alex Christian Yde; Gyhrs, Mette Louise; Holmes, Edward C.; Cui, Jie;

Published:

Oct 2012

Source:

Emerg Infect Dis. 18(10):1694-1696.

File Type:

[PDF - 183.39 KB]