Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Drexler, Jan Felix ; de Souza Luna, Luciano Kleber ; Stöcker, Andreas ; Almeida, Patrícia Silva ; Ribeiro, Tereza Cristina Medrado ; ... More +
Drexler, Jan Felix ; de Souza Luna, Luciano Kleber ; Stöcker, Andreas ; Almeida, Patrícia Silva ; Ribeiro, Tereza Cristina Medrado ; Petersen, Nadine ; Herzog, Petra ; Pedroso, Célia ; Huppertz, Hans Iko ; da Costa Ribeiro, Hugo ; Baumgarte, Sigrid ; Drosten, Christian Less -
Description:
Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis-like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients <6 years of age. Viral loads were 283,305-5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%-77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified.
Subject:
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Adolescent
Adult
Aged
Aged, 80 And Over
Base Sequence
Cardiovirus Infections
Child
Child, Preschool
Feces
Gastroenteritis
Humans
Infant
Infant, Newborn
Middle Aged
Oligonucleotides
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral

Source:
Emerg Infect Dis. 14(9):1398-1405
Pubmed ID:
18760006
Pubmed Central ID:
PMC2603095
Document Type:
Journal Article
Place as Subject:
Brazil ; Germany
Brazil ; Germany Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:afacc69aca40fedda05a6150902871df5c3373cacd54955c9aefea864cb99cdc
File Type:

Supporting Files

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