Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans

Drexler, Jan Felix; de Souza Luna, Luciano Kleber; Stöcker, Andreas; Almeida, Patrícia Silva; Ribeiro, Tereza Cristina Medrado; Petersen, Nadine; Herzog, Petra; Pedroso, Célia; Huppertz, Hans Iko; da Costa Ribeiro, Hugo; Baumgarte, Sigrid; Drosten, Christian

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Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans

Published Date:

Sep 2008

Source:

Emerg Infect Dis. 14(9):1398-1405

Language:

English

[PDF-251.07 KB]

Details:

Personal Authors:

Drexler, Jan Felix ; de Souza Luna, Luciano Kleber ; Stöcker, Andreas ; Almeida, Patrícia Silva ; Ribeiro, Tereza Cristina Medrado ; ... More ▼

Keywords:

[+]

Pubmed ID:

18760006

Pubmed Central ID:

PMC2603095

Description:

Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis-like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients <6 years of age. Viral loads were 283,305-5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%-77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

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