Phylogenetics and Pathogenesis of Early Avian Influenza Viruses (H5N1), Nigeria

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Aiki-Raji, Comfort O. ; Aguilar, Patricia V. ; Kwon, Yong-Kuk ; Goetz, Sue ; Suarez, David L. ; Jethra, Aashish I. ; Nash, Oyekanmi ; Adeyefa, Christopher A.O. ; Adu, Festus D. ; Swayne, David ; Basler, Christopher F.
• Description:
  Three highly pathogenic avian influenza subtype H5N1 and 4 Newcastle disease viruses were isolated from sick or dead chickens in southwestern Nigeria. Sequencing and phylogenetic analysis placed them within H5N1 subclade 2.2.2. Intravenous and intranasal pathogenicity tests produced systemic disease with vascular endothelial cell tropism in chickens.
• Subjects:
  Animals Brain Chickens Endothelium, Vascular Inflammation Influenza A Virus, H5N1 Subtype Influenza In Birds Lung Myocardium Necrosis Phylogeny Virulence

  More +
• Source:
  Emerg Infect Dis. 14(11):1753-1755
• Pubmed ID:
  18976562
• Pubmed Central ID:
  PMC2630749
• Document Type:
  Journal Article
• Funding:
  P01 AI058113/AI/NIAID NIH HHS/United States ; U54 AI057158/AI/NIAID NIH HHS/United States ; AI057158/AI/NIAID NIH HHS/United States
• Place as Subject:
  Nigeria
• Location:
  Africa
• Volume:
  14
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4aaddf4971cfbe440f4ef9b975b7a53ea7f6d7999a30980ea5c9f46a5a0fc92e
• Download URL:
  https://stacks.cdc.gov/view/cdc/17304/cdc_17304_DS1.pdf
• File Type:
  [PDF - 235.97 KB ]