Antimicrobial Drug–Selection Markers for Burkholderia pseudomallei and B. mallei

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Schweizer, Herbert P. ; Peacock, Sharon J.
• Description:
  Genetic research into the select agents Burkholderia pseudomallei and B. mallei is currently hampered by a paucity of approved antimicrobial drug-selection markers. The strict regulations imposed on researchers in the United States but not in other parts of the world lead to discrepancies in practice, hinder distribution of genetically modified strains, and impede progress in the field. Deliberation and decisions regarding alternative selection markers (antimicrobial and nonantimicrobial drugs) by the international community, regulatory authorities, and funding agencies are needed.
• Subjects:
  Animals Anti-Bacterial Agents Antimicrobial Drug–selection Markers Burkholderia Mallei Burkholderia Pseudomallei Drug Resistance, Bacterial Genetic Markers Glanders Humans Melioidosis Microbial Sensitivity Tests Perspective Select Agents Selection, Genetic

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• Source:
  Emerg Infect Dis. 14(11):1689-1692
• Pubmed ID:
  18976550
• Pubmed Central ID:
  PMC2630740
• Document Type:
  Journal Article
• Funding:
  Wellcome Trust/United Kingdom ; U54 AI065357/AI/NIAID NIH HHS/United States
• Volume:
  14
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6575e4e675624fa37e0bb739241e3467507ebaffa4765165dc782cd5c5d2b59f
• Download URL:
  https://stacks.cdc.gov/view/cdc/17272/cdc_17272_DS1.pdf
• File Type:
  [PDF - 135.03 KB ]