Microbial Interactions during Upper Respiratory Tract Infections

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pettigrew, Melinda M. ; Gent, Janneane F. ; Revai, Krystal ; Patel, Janak A. ; Chonmaitree, Tasnee
• Description:
  Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus often colonize the nasopharynx. Children are susceptible to bacterial infections during or soon after upper respiratory tract infection (URI). We describe colonization with these 4 bacteria species alone or in combination during URI. Data were from a prospective cohort of healthy children 6 to 36 months of age followed up for 1 year. Analyses of 968 swabs from 212 children indicated that S. pneumoniae colonization is negatively associated with colonization by H. influenzae. Competitive interactions shifted when H. influenzae and M. catarrhalis colonized together. In this situation, the likelihood of colonization with all 3 species is higher. Negative associations were identified between S. pneumoniae and S. aureus and between H. influenzae and S. aureus. Polymicrobial interactions differed by number and species of bacteria present. Antimicrobial therapy and vaccination strategies targeting specific bacterial species may alter the flora in unforeseen ways.
• Subjects:
  Child, Preschool Children Cohort Studies Colonization Competition Female Haemophilus Infections Haemophilus Influenzae Humans Infant Interference Male Moraxella (Branhamella) Catarrhalis Moraxella Catarrhalis Moraxellaceae Infections Nasopharynx Otitis Media Polymicrobial Prospective Studies Research Respiratory Tract Infections Staphylococcal Infections Staphylococcus Aureus Streptococcus Pneumoniae Superinfection Upper Respiratory Tract Infection

  More +
• Source:
  Emerg Infect Dis. 14(10):1584-1591
• Pubmed ID:
  18826823
• Pubmed Central ID:
  PMC2609881
• Document Type:
  Journal Article
• Funding:
  R01 DC005841/DC/NIDCD NIH HHS/United States ; R01 AI068043/AI/NIAID NIH HHS/United States ; M01 RR000073/RR/NCRR NIH HHS/United States ; M01 RR 00073/RR/NCRR NIH HHS/United States ; DC 005841-02S1/DC/NIDCD NIH HHS/United States
• Volume:
  14
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d9795160b6ffa9dde86956ff8df9351dbc2e4bf2deaa2f2d6c1c3e9dd6dc8abf
• Download URL:
  https://stacks.cdc.gov/view/cdc/17204/cdc_17204_DS1.pdf
• File Type:
  [PDF - 155.49 KB ]